Department of Traditional Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
J Tradit Chin Med. 2022 Jun;42(3):332-343. doi: 10.19852/j.cnki.jtcm.2022.03.002.
To investigate the and studies of natural compounds and medicinal plants with anti-coronavirus activity.
A systematic review was performed based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses and Animal Research: Reporting of experiments guidelines to find data for medicinal plants and natural products effective against human coronaviruses in or studies. Studies published up to September 6, 2020 were included. Studies ( or ) reporting the effect of medicinal plants and natural products or their derivatives on human coronavirus were included RESULTS: Promising anti-coronavirus effects are seen with different herbal compounds like some diterpenoids, sesquiterpenoids, and three compounds in tea with 3CLpro inhibiting effect of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV); Hirsutenone, Six cinnamic amides and bavachinin are PLpro inhibitors and Tanshinones are active on both 3CLpro and PLpro. Some flavonoid compounds of Citrus fruits act on Immun-oregulation and target angiotensin-converting enzyme 2 which is used by SARS-COV for entry. Virus helicase is possibly inhibited by two compounds myricetin and scutellarein.
This review shows that complementary medicine have the potential for new drug discovery against coronavirus. Further research is needed before definitive conclusions can be made concerning the safety and efficacy of the use of these medicinal plants.
研究具有抗冠状病毒活性的天然化合物和药用植物。
根据系统评价和荟萃分析的首选报告项目以及动物研究报告实验指南进行系统评价，以寻找针对人类冠状病毒的药用植物和天然产物的有效数据。纳入截至 2020 年 9 月 6 日发表的研究。纳入研究（或）报告药用植物和天然产物或其衍生物对人类冠状病毒的影响。
不同的草药化合物如一些二萜类、倍半萜类和茶中的三种具有 3CLpro 抑制作用的化合物具有有希望的抗冠状病毒作用严重急性呼吸系统综合征冠状病毒（SARS-CoV）；相思豆酮、六肉桂酰胺和黄华碱是 PLpro 抑制剂，丹参酮对 3CLpro 和 PLpro 均有活性。一些柑橘类水果的类黄酮化合物可作用于免疫调节，并以血管紧张素转换酶 2 为靶点，SARS-COV 以此进入细胞。两种化合物杨梅素和圣草酚可能抑制病毒解旋酶。
本综述表明，补充医学具有发现针对冠状病毒的新药的潜力。在确定这些药用植物的安全性和疗效之前，还需要进一步的研究。
