Neurological department, groupe hospitalier Paris Saint-Joseph, Paris, France; Université Paris Cité, Paris, France.
Neurological department, groupe hospitalier Paris Saint-Joseph, Paris, France; Université Paris Cité, Paris, France.
Rev Neurol (Paris). 2022 Oct;178(8):802-807. doi: 10.1016/j.neurol.2022.03.014. Epub 2022 May 13.
COVID-19 due to SARS-CoV-2 virus is a new cause of severe acute respiratory syndrome (SARS). Little is known about the short-term cognitive prognosis for these patients. We prospectively evaluated basic cognitive functions shortly after care in the intensive care unit (ICU) and three months later in post-ICU COVID-19 patients.
We performed a prospective single-center study in our institution in Paris. Patients with SARS-CoV-2 SARS were prospectively recruited via our ICU. Patients were evaluated using standardized cognitive tests at baseline and at three months' follow-up. Our primary endpoint was the evolution of the following five global tests: MMSE, FAB, oral naming test, Dubois five words test and MADRS.
We explored 13 patients at baseline and follow-up. All patients had cognitive impairment at baseline but they all improved at three months, significantly on two of the five global tests after Bonferroni correction for multiple testing: MMSE (median 18 (IQR [15-22]) and 27 (IQR [27-29]) respectively, P=0.002) and FAB test (median 14 (IQR [14-17]) and 17 (IQR [17,18]) respectively, P=0.002).
We report here the first longitudinal data on short-term cognitive impairment after intensive care in COVID-19 patients. We found acute and short-term cognitive impairment but significant improvement at three months. This pattern does not seem to differ from other causes of post-intensive care syndrome.
由 SARS-CoV-2 病毒引起的 COVID-19 是严重急性呼吸系统综合征（SARS）的新病因。人们对这些患者的短期认知预后知之甚少。我们在入住重症监护病房（ICU）后不久以及 COVID-19 患者入住 ICU 后三个月，前瞻性评估了基本认知功能。
我们在巴黎的机构进行了一项前瞻性单中心研究。通过我们的 ICU 前瞻性招募 SARS-CoV-2 SARS 患者。患者在基线和三个月随访时使用标准化认知测试进行评估。我们的主要终点是以下五个整体测试的演变：MMSE、FAB、口头命名测试、杜布瓦 5 字测试和 MADRS。
我们在基线和随访时共探索了 13 例患者。所有患者在基线时均存在认知障碍，但在三个月时均有所改善，在经过多重测试的 Bonferroni 校正后，五个整体测试中的两项有显著改善：MMSE（中位数 18（IQR [15-22]）和 27（IQR [27-29]），P=0.002）和 FAB 测试（中位数 14（IQR [14-17]）和 17（IQR [17,18]），P=0.002）。
我们在此报告了 COVID-19 患者入住 ICU 后短期认知障碍的首批纵向数据。我们发现急性和短期认知障碍，但在三个月时明显改善。这种模式似乎与其他 ICU 后综合征的病因不同。
