Cai Meng, Ding Yi, Wang Lei, Huang Leilei, Lu Xinhua, Cai Yuanli
College of Chemistry, Chemical Engineering and Materials Science, State-Local Joint Engineering Laboratory for Novel Functional Polymer Materials, Soochow University, Suzhou 215123, China.
ACS Macro Lett. 2018 Feb 20;7(2):208-212. doi: 10.1021/acsmacrolett.8b00005. Epub 2018 Jan 30.
Nanostructured polyion complexes (PICs) are expected to serve as novel platforms to stabilize and deliver drugs, proteins, and nucleic acids. Yet, traditional self-assembly suffers from lack of scale-up and reproducibility. Particularly for one-component PICs, only spheres are available to date. Here, we report an efficient and scalable strategy to prepare one-component low-dimensional PICs. It involves visible-light-mediated RAFT iterative polymerization of opposite-charge monomers at 25% w/w solids in water at 25 °C. Sphere-film-vesicle transition and charge-/medium-tunable shape selectivity are reported. One-component PIC nanowire, ultrathin film, vesicle, tube, and surface-charged vesicle are easily prepared, and vesicle-polymerization is fulfilled, using this new strategy. This strategy provides a general platform to prepare one-component low-dimensional PICs with tailorable morphologies and high reproducibility on commercially viable scale under eco-friendly conditions.
纳米结构聚离子复合物（PICs）有望成为稳定和递送药物、蛋白质及核酸的新型平台。然而，传统的自组装方法存在放大和可重复性方面的不足。特别是对于单一组分的PICs，迄今为止只有球形结构。在此，我们报告了一种高效且可扩展的策略来制备单一组分的低维PICs。该策略涉及在25℃下于水中25% w/w的固含量下通过可见光介导的RAFT迭代聚合相反电荷的单体。报道了球-膜-囊泡转变以及电荷/介质可调的形状选择性。使用这种新策略可以轻松制备单一组分的PIC纳米线、超薄膜、囊泡、管和表面带电囊泡，并实现囊泡聚合。该策略提供了一个通用平台，可在生态友好条件下以商业可行的规模制备具有可定制形态和高重现性的单一组分低维PICs。
