无菌性脑膜炎患儿脑脊液中的干扰素-γ

Interferon-gamma in cerebrospinal fluid of children with aseptic meningitis.

作者信息

Tang R B, Chen S J, Wu K K, Lee B H, Chen P Y

机构信息

Department of Pediatrics, Veterans General Hospital-Taipei, Taiwan, R.O.C.

出版信息

Zhonghua Yi Xue Za Zhi (Taipei). 1997 Apr;59(4):248-53.

PMID:9216121

Abstract

BACKGROUND

Certain cytokines may contribute to the sequence of events that lead to meningeal inflammation in bacterial meningitis. However, their role in viral meningitis is not so less well defined. We determined the cytokines levels in the cerebrospinal fluid (CSF) of children with aseptic meningitis and discussed their relationship with clinical and laboratory findings.

METHODS

We determined the concentrations of interleukin-1 beta (IL-1 beta), interferon-gamma (IFN-gamma) and granulocyte-macrophage colony-stimulating factor (GM-CSF) in the CSF of 62 patients with aseptic meningitis including 17 patients with culture-proved enteroviral meningitis, and from 19 control acute febrile patients without meningitis.

RESULTS

The GM-CSF in the cerebrospinal fluid was detected from one of the 62 patients with aseptic meningitis and none of the 19 controls. Fourteen (23%) of the 62 patients with aseptic meningitis and 2 (10.5%) of 19 controls had detectable IL-1 beta. There was no significant difference in IL-1 beta levels between patients with aseptic meningitis (4.4 +/- 11.4 pg/ml) and control group (2.4 +/- 7.7 pg/ml). The CSF IFN-gamma level was detectable in 40 (65%) of 62 patients and 6 (31.6%) of 19 controls. The mean CSF IFN-gamma concentration was significantly higher in patients with aseptic meningitis when compared with that in control group (37.9 +/- 48.8 pg/ml vs 17.5 +/- 29.7 pg/ml; p = 0.007).

CONCLUSIONS

IFN-gamma was detectable in the CSF in 65% of patients with aseptic meningitis and the role of interferon-gamma remains to be determined.

摘要

背景

某些细胞因子可能参与导致细菌性脑膜炎脑膜炎症的一系列事件。然而，它们在病毒性脑膜炎中的作用尚不十分明确。我们测定了无菌性脑膜炎患儿脑脊液（CSF）中的细胞因子水平，并探讨了它们与临床及实验室检查结果的关系。

方法

我们测定了62例无菌性脑膜炎患者脑脊液中白细胞介素-1β（IL-1β）、干扰素-γ（IFN-γ）和粒细胞-巨噬细胞集落刺激因子（GM-CSF）的浓度，其中包括17例经培养证实为肠道病毒脑膜炎的患者，以及19例无脑膜炎的急性发热对照患者。

结果

62例无菌性脑膜炎患者中有1例脑脊液中检测到GM-CSF，19例对照患者均未检测到。62例无菌性脑膜炎患者中有14例（23%）、19例对照患者中有2例（10.5%）检测到IL-1β。无菌性脑膜炎患者（4.4±11.4 pg/ml）与对照组（2.4±7.7 pg/ml）的IL-1β水平无显著差异。62例患者中有40例（65%）、19例对照患者中有6例（31.6%）脑脊液中IFN-γ水平可检测到。与对照组相比，无菌性脑膜炎患者脑脊液中IFN-γ的平均浓度显著更高（37.9±48.8 pg/ml对17.5±29.7 pg/ml；p = 0.007）。