Nelson G J, Kelley D S, Schmidt P C, Serrato C M
Lipids. 1987 Feb;22(2):88-94. doi: 10.1007/BF02534859.
The liver and plasma lipids and fatty acid composition of rats fed synthetic diets of differing fat type and content were studied. All animals were starved for 48 hr and then refed a high carbohydrate, fat-free diet for 48 hr. They were then divided into three groups and fed for an additional 48 hrs the following: group 1, the fat-free diet; group 2, a diet containing 44% of calories from corn oil; and group 3, a diet containing 44% calories from completely hydrogenated soybean oil. The total lipid concentration of the liver in the animals on the fat-free diet was elevated at 72 and 96 hr. The addition of either saturated or unsaturated fat in the diet at 48 hr prevented this accumulation. The total phospholipid and cholesterol concentrations of the liver were relatively uninfluenced by any diet in this study. Plasma total fatty acid concentration was elevated at 72 hr in the animals on a fat-free diet compared to those fed the stock diet, starved for 48 hr or fed the fat-containing diets. By 96 hr, however, plasma fatty acid concentrations in all groups were similar to those in animals fed only the stock diet. The release of de novo synthesized fatty acids into plasma from the liver was strongly inhibited by dietary fat, either saturated or polyunsaturated. With the fat-free diet there was a significant increase in the saturated and monounsaturated fatty acids in both liver and plasma.(ABSTRACT TRUNCATED AT 250 WORDS)
研究了喂食不同脂肪类型和含量的合成日粮的大鼠的肝脏和血浆脂质及脂肪酸组成。所有动物均饥饿48小时，然后重新喂食高碳水化合物、无脂肪日粮48小时。然后将它们分为三组，并在接下来的48小时内喂食以下日粮：第1组，无脂肪日粮；第2组，一种含有44%玉米油热量的日粮；第3组，一种含有44%完全氢化大豆油热量的日粮。无脂肪日粮组动物肝脏中的总脂质浓度在72小时和96小时时升高。在48小时时日粮中添加饱和或不饱和脂肪可防止这种积累。在本研究中，任何日粮对肝脏的总磷脂和胆固醇浓度影响相对较小。与喂食基础日粮、饥饿48小时或喂食含脂肪日粮的动物相比，无脂肪日粮组动物的血浆总脂肪酸浓度在72小时时升高。然而，到96小时时，所有组的血浆脂肪酸浓度与仅喂食基础日粮的动物相似。日粮脂肪（无论是饱和脂肪还是多不饱和脂肪）都会强烈抑制肝脏中从头合成的脂肪酸释放到血浆中。采用无脂肪日粮时，肝脏和血浆中的饱和脂肪酸和单不饱和脂肪酸均显著增加。（摘要截断于250字）
