Galeoto G, Berardi A, Colalelli F, Pelosin E, Mezzarobba S, Avanzino L, Valente D, Tofani M, Fabbrini G
Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
IRCCS Neuromed, Pozzilli, IS, Italy.
Clin Ter. 2022 May 25;173(3):243-248. doi: 10.7417/CT.2022.2427.
Strong evidence shows that symptoms in individuals with Parkinson's Disease (PD) restrict both their independence and social participation, leading to a low Quality of Life (QoL). Conversely, a reduced QoL has a negative impact on symptoms. The aim is to evaluate the correlation between QoL and severity of PD by assessing the presence of an optimal cut-off point on the Parkinson's disease questionnaire (PDQ-39) as related to the Hoehn &Yahr (H&Y) scale in a cohort of Italian adults with PD.
A multicenter, cross-sectional study was performed. This study was conducted on a cohort of consecutive individuals. All participants were evaluated with the PDQ-39, and the severity of PD was recorded according to the H&Y scale by a neurologist. Receiver op-erating characteristic (ROC) curves and coordinates, visually inspected, were used to find cut-off points with optimal sensitivity and specificity. These were in turn used to determine the optimal PDQ-39 cut-off score for identifying disease severity according to H&Y stages.
513 individuals were included in the study. The ROC curve analysis showed that QoL worsened with an increase in disease severity and age. Moreover, QoL was worse in females.
The results of this study allowed for the correlation of QoL and disease severity in a cohort of individuals with PD. With this cut-off point, it is now possible to make a determination of QoL of an individual with PD at a certain stage of the disease, in a specific age range, and of a particular gender.
有力证据表明，帕金森病（PD）患者的症状限制了他们的独立性和社会参与度，导致生活质量（QoL）低下。相反，生活质量降低对症状有负面影响。目的是通过评估帕金森病问卷（PDQ-39）上与Hoehn&Yahr（H&Y）量表相关的最佳临界点的存在情况，来评估意大利成年PD患者队列中生活质量与PD严重程度之间的相关性。
进行了一项多中心横断面研究。该研究针对一组连续的个体进行。所有参与者均接受了PDQ-39评估，神经科医生根据H&Y量表记录PD的严重程度。使用经视觉检查的受试者操作特征（ROC）曲线和坐标来找到具有最佳敏感性和特异性的临界点。这些临界点进而用于确定根据H&Y分期识别疾病严重程度的最佳PDQ-39临界分数。
513名个体纳入研究。ROC曲线分析表明，生活质量随着疾病严重程度和年龄的增加而恶化。此外，女性的生活质量更差。
本研究结果揭示了PD患者队列中生活质量与疾病严重程度之间的相关性。有了这个临界点，现在就可以确定处于疾病特定阶段、特定年龄范围和特定性别的PD患者的生活质量。
