Department of Chemistry, Visva-Bharati (A Central University), Santiniketan 731235, India.
Org Biomol Chem. 2022 Jun 8;20(22):4496-4511. doi: 10.1039/d2ob00688j.
Chiral organoboronates have emerged as a key intermediate in the development of pharmaceuticals and materials science. Therefore, several attempts have been made to design various synthetic methods to easily furnish these compounds during the past few decades. , asymmetric catalysis has been increasing rapidly as a viable, practical and beneficial strategy for their preparation. In this respect, recent years have witnessed significant progress in aliphatic C-H borylation as the generated carbon-boron bonds are largely utilized to produce other carbon-carbon, carbon-nitrogen and carbon-oxygen bonds. This review presents a detailed overview and analysis of transition metal-catalyzed asymmetric C(sp)-H borylation strategies. Overall, it assembles all the recent developments in this particular synthetic avenue up to March 2022.
手性有机硼酸盐已成为药物和材料科学发展的关键中间体。因此，在过去几十年中，人们尝试设计了各种合成方法，以便于制备这些化合物。不对称催化作为一种可行、实用和有益的策略，在其制备中得到了迅速发展。在这方面，近年来脂肪族 C-H 硼化反应取得了显著进展，因为生成的碳-硼键可广泛用于生成其他碳-碳、碳-氮和碳-氧键。本综述详细概述和分析了过渡金属催化的不对称 C(sp 3 )-H 硼化策略。总的来说，它汇集了截至 2022 年 3 月这一特定合成途径的所有最新进展。
