Furlaneto Flávia, Ishikawa Karin Hitomi, Messora Michel Reis, Mayer Marcia P A
Department of Oral Surgery and Periodontology, School of Dentistry of Ribeirão Preto, University of São Paulo, São Paulo, Brazil.
Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Adv Exp Med Biol. 2022;1373:353-375. doi: 10.1007/978-3-030-96881-6_19.
Scaling and root planing is the gold standard for the treatment of periodontitis, but administration of systemic antibiotics may be needed especially for sites with deep probing depths, or in the presence of comorbidities. However, treated sites are subject to recolonization with a microbiota similar to that present before therapy, and supportive periodontal therapy is employed after the treatment of active disease. The use of beneficial organisms, known as probiotics, seems an attractive proposal to promote a healthy associated subgingival microbiome and to control inflammation for the management of periodontitis. The mechanisms underlying the benefits promoted by probiotics involve interference on periodontopathogens, modulation of the exacerbated immune host response and the ability to restore the integrity of the epithelial barrier on mucosa surfaces. This review examines the scientific data related to the effects of probiotics on the treatment of periodontal diseases and addresses the future approaches necessary for their implementation.
龈上洁治术和根面平整术是治疗牙周炎的金标准，但对于探诊深度较深的部位或存在合并症的情况，可能需要使用全身性抗生素。然而，治疗后的部位会再次被类似于治疗前存在的微生物群定植，并且在活动性疾病治疗后采用支持性牙周治疗。使用有益生物，即益生菌，似乎是促进健康的龈下微生物群和控制炎症以管理牙周炎的一个有吸引力的提议。益生菌促进益处的潜在机制包括干扰牙周病原体、调节加剧的免疫宿主反应以及恢复黏膜表面上皮屏障完整性的能力。本综述研究了与益生菌对牙周疾病治疗效果相关的科学数据，并探讨了其实施所需的未来方法。
