National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan.
Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan.
Sci Rep. 2022 May 25;12(1):8866. doi: 10.1038/s41598-022-12939-2.
This study aimed to examine the association between conduct problems and mood disorders, and to evaluate the mediating roles of personality traits in it. Adult participants (N = 309), for which patients with major depressive disorder (MDD) or bipolar disorder (BD), and controls without major psychiatric history were recruited. Juvenile conduct problem was defined by the items in Composite International Diagnosis Interview. We assessed personality traits of extraversion and neuroticism. Multiple mediation model was performed to investigate the intervening effect of personality traits between juvenile conduct problems and adulthood mood disorders. Participants had on average 2.7 symptoms of conduct problems, and 43.4% had conduct problems. Having more symptoms of conduct problems was associated with a higher likelihood of BD (OR = 1.20). Higher neuroticism was associated with elevated risks of both MDD and BD. There was no direct effect of binary conduct problems on the risk of BD, and showed significant total indirect effect mediated by neuroticism for BD (OR = 1.49; bias-corrected and accelerated 95% CI = 1.10-2.05), but not through extraversion. Conduct problems defined as a continuous variable had a direct effect on the risk of adult MDD (OR = 1.36; bias-corrected and accelerated 95% CI = 1.05-1.76), while had an indirect effect on the risk of BD via the mediation of neuroticism (OR = 1.08; bias-corrected and accelerated 95% CI = 1.02-1.14). Neuroticism mediates between the association of juvenile conduct problems and adult BD. This finding raises our attention to assess personality traits in individuals with juvenile conduct problems for timely intervention strategies of reducing the vulnerability for developing mood disorders.
这项研究旨在探讨品行问题与心境障碍之间的关联，并评估人格特质在其中的中介作用。研究招募了成年参与者（N=309），其中包括患有重性抑郁障碍（MDD）或双相情感障碍（BD）的患者，以及没有重大精神病史的对照组。青少年品行问题通过复合国际诊断访谈中的项目来定义。我们评估了外向和神经质等人格特质。采用多重中介模型来研究人格特质在青少年品行问题与成年期心境障碍之间的干预作用。参与者平均有 2.7 项品行问题症状，其中 43.4%有品行问题。品行问题症状越多，患 BD 的可能性越高（OR=1.20）。神经质程度越高，患 MDD 和 BD 的风险也越高。二分类品行问题对 BD 风险没有直接影响，但通过神经质有显著的总间接影响（OR=1.49；校正偏倚和加速 95%CI=1.10-2.05），但通过外向性则没有。将品行问题定义为连续变量，对成年 MDD 的发病风险有直接影响（OR=1.36；校正偏倚和加速 95%CI=1.05-1.76），而通过神经质的中介作用对 BD 的发病风险有间接影响（OR=1.08；校正偏倚和加速 95%CI=1.02-1.14）。神经质在青少年品行问题与成年 BD 之间的关联中起中介作用。这一发现提醒我们注意评估有青少年品行问题的个体的人格特质，以便及时采取干预策略，降低其患心境障碍的脆弱性。
