彻底变革：含偶氮聚（β-硫酯）的热触发降解
Radical Departure: Thermally-Triggered Degradation of Azo-Containing Poly(β-thioester)s.
作者信息
Sun Hao, Dobbins Daniel J, Dai Yuqiong, Kabb Christopher P, Wu Shijian, Alfurhood Jawaher A, Rinaldi Carlos, Sumerlin Brent S
机构信息
George and Josephine Butler Polymer Research Laboratory, Center for Macromolecular Science and Engineering, Department of Chemistry, ‡Department of Chemical Engineering, and §J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, P.O. Box 117200, Gainesville, Florida, United States.
George and Josephine Butler Polymer Research Laboratory, Center for Macromolecular Science and Engineering, Department of Chemistry, Department of Chemical Engineering, and §J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, P.O. Box 117200, Gainesville, Florida, United States.
出版信息
ACS Macro Lett. 2016 Jun 21;5(6):688-693. doi: 10.1021/acsmacrolett.6b00327. Epub 2016 May 19.
The design and synthesis of a new class of thermally-labile poly(β-thioester)s is reported. Aliphatic azo linkages were incorporated into the main chain of the polymers to allow for degradation to lower molecular weights upon heating. These polymers displayed a temperature-dependent degradation profile with a significant increase in decomposition rate as the temperature was raised from 60 to 95 °C. This approach was further extended to prepare amphiphilic triblock copolymers containing poly(β-thioester)s and poly(ethylene glycol) (PEG). The resulting block copolymers were capable of self-assembly into micelles in water. Moreover, the assembled nanoparticles underwent dissociation as a result of exposure to heat.
报道了一类新型热不稳定聚（β-硫酯）的设计与合成。脂肪族偶氮键被引入到聚合物主链中，以便在加热时降解为较低分子量的产物。这些聚合物呈现出温度依赖性的降解曲线，当温度从60℃升高到95℃时，分解速率显著增加。该方法进一步扩展到制备含有聚（β-硫酯）和聚乙二醇（PEG）的两亲性三嵌段共聚物。所得的嵌段共聚物能够在水中自组装成胶束。此外，组装后的纳米颗粒由于受热而发生解离。
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