Dai Yuqiong, Sun Hao, Pal Sunirmal, Zhang Yunlu, Park Sangwoo, Kabb Christopher P, Wei Wei David, Sumerlin Brent S
George & Josephine Butler Polymer Research Laboratory , Center for Macromolecular Science & Engineering , Department of Chemistry , University of Florida , PO Box 117200 , Gainesville , FL 32611-7200 , USA . Email:
Department of Chemistry , Center for Nanostructured Electronic Materials , University of Florida , PO Box 117200 , Gainesville , FL 32611-7200 , USA.
Chem Sci. 2017 Mar 1;8(3):1815-1821. doi: 10.1039/c6sc04650a. Epub 2016 Dec 13.
Responsive systems sensitive to near-infrared (NIR) light are promising for triggered release due to efficient deep tissue penetration of NIR irradiation relative to higher energy sources (, UV), allowing for spatiotemporal control over triggering events with minimal potential for tissue damage. Herein, we report star polymers containing thermally-labile azo linkages that dissociate during conventional heating or during localized heating the photothermal effect upon NIR irradiation. Controlled release during conventional heating was investigated for the star polymers loaded with a model dye, with negligible release being observed at 25 °C and >80% release at 90 °C. Star polymers co-loaded with NIR-responsive indocyanine green showed rapid dye release upon NIR irradiation ( ≥ 715 nm) due to the photothermally-induced degradation of azo linkages within the cores of the star polymers. This approach provides access to a new class of delivery and release systems that can be triggered by noninvasive external stimulation.
对近红外（NIR）光敏感的响应系统因近红外辐射相对于高能光源（如紫外线）具有高效的深部组织穿透能力，有望实现触发释放，从而能够以最小的组织损伤可能性对触发事件进行时空控制。在此，我们报道了含有热不稳定偶氮键的星形聚合物，这些偶氮键在传统加热或近红外辐射产生光热效应时的局部加热过程中会发生解离。研究了负载模型染料的星形聚合物在传统加热过程中的控释情况，在25℃时释放可忽略不计，而在90℃时释放超过80%。共负载近红外响应性吲哚菁绿的星形聚合物在近红外辐射（≥715nm）下由于星形聚合物核心内偶氮键的光热诱导降解而显示出快速的染料释放。这种方法提供了一种新型的递送和释放系统，可通过非侵入性外部刺激触发。
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