Kim Young-Min, Kim Chang-Ho, Song Soo-Chang
Center for Biomaterials, Korea Institute of Science and Technology (KIST), Seoul, 02792, Korea.
Department of Medical Engineering, Korea University of Science and Technology (UST), Daejeon, 34113, Korea.
ACS Macro Lett. 2016 Mar 15;5(3):297-300. doi: 10.1021/acsmacrolett.6b00008. Epub 2016 Feb 11.
We developed an injectable chemical drug/gene dual delivery platform system for long-term combination therapy. Ternary nanosized thermosensitive polymer/chemical drug/gene-(PCG) complexes showing sol-gel transition were prepared by simple mixing of three components via hydrophobic and ionic interaction. The PCG complex hydrogel showed sustained release of chemical drug and genes for 40 days without denaturalization of genes in vitro. Dual delivery-mediated anticancer effects of PCG complexes were shown in vitro and in an in vivo xenograft model for up to 1 month. Therefore, this dual delivery platform is expected to be a new effective system for treatment of diseases via long-term chemical drug/gene combination therapy.
我们开发了一种用于长期联合治疗的可注射化学药物/基因双递送平台系统。通过三种组分经疏水和离子相互作用简单混合制备了具有溶胶-凝胶转变的三元纳米级热敏聚合物/化学药物/基因（PCG）复合物。PCG复合水凝胶在体外可实现化学药物和基因的持续释放达40天，且基因不会变性。PCG复合物的双递送介导的抗癌作用在体外和体内异种移植模型中均得到证实，长达1个月。因此，这种双递送平台有望成为通过长期化学药物/基因联合治疗疾病的新型有效系统。
