Zholudeva Lyandysha V, Lane Michael A
Gladstone Institutes, San Francisco, CA, USA.
Marion Murray Spinal Cord Research Center, Philadelphia, PA, USA.
Neurosci Insights. 2022 May 19;17:26331055221101607. doi: 10.1177/26331055221101607. eCollection 2022.
Interest in spinal interneurons (SpINs), their heterogeneity in the naive spinal cord and their varying responses to central nervous system injury or disease has been steadily increasing. Our recent review on this topic highlights the vast phenotypic heterogeneity of SpINs and the efforts being made to better identify and classify these neurons. As our understanding of SpIN phenotype, connectivity, and neuroplastic capacity continues to expand, new therapeutic targets are being revealed and novel treatment approaches developed to harness their potential. Here, we expand on that initial discussion and highlight how SpINs can be used to develop advanced, targeted cellular therapies and personalized medicines.
人们对脊髓中间神经元（SpINs）、其在未受损脊髓中的异质性以及它们对中枢神经系统损伤或疾病的不同反应的兴趣一直在稳步增加。我们最近关于这个主题的综述强调了SpINs巨大的表型异质性以及为更好地识别和分类这些神经元所做的努力。随着我们对SpIN表型、连接性和神经可塑性能力的理解不断扩展，新的治疗靶点正在被揭示，并且正在开发新的治疗方法来利用它们的潜力。在这里，我们扩展了最初的讨论，并强调了SpINs如何可用于开发先进的、有针对性的细胞疗法和个性化药物。
