脊髓中间神经元作为损伤或疾病后神经可塑性的守门员。
Spinal Interneurons as Gatekeepers to Neuroplasticity after Injury or Disease.
机构信息
Gladstone Institutes, San Francisco, California, 94158
Department of Cell Biology & Neuroscience, Rutgers University, The State University of New Jersey, New Jersey, 08854.
出版信息
J Neurosci. 2021 Feb 3;41(5):845-854. doi: 10.1523/JNEUROSCI.1654-20.2020. Epub 2021 Jan 20.
Abstract
Spinal interneurons are important facilitators and modulators of motor, sensory, and autonomic functions in the intact CNS. This heterogeneous population of neurons is now widely appreciated to be a key component of plasticity and recovery. This review highlights our current understanding of spinal interneuron heterogeneity, their contribution to control and modulation of motor and sensory functions, and how this role might change after traumatic spinal cord injury. We also offer a perspective for how treatments can optimize the contribution of interneurons to functional improvement.
摘要
脊髓中间神经元是完整中枢神经系统中运动、感觉和自主功能的重要促进剂和调制器。现在广泛认为，这种异质神经元群体是可塑性和恢复的关键组成部分。这篇综述强调了我们目前对脊髓中间神经元异质性的理解，它们对运动和感觉功能的控制和调制的贡献，以及这种作用在创伤性脊髓损伤后如何变化。我们还提供了一个视角，说明如何通过治疗来优化中间神经元对功能改善的贡献。
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