Department of Chemistry and Chemical Engineering , Inner Mongolia University , Hohhot 010021 , P.R. China.
Org Lett. 2018 Mar 16;20(6):1538-1541. doi: 10.1021/acs.orglett.8b00106. Epub 2018 Mar 6.
A novel palladium-catalyzed domino cyclization/alkylation of terminal alkynes was achieved for the synthesis of alkynyl-functionalized 3,3-disubstituted azaindoline derivatives under air atmosphere conditions. Various types of terminal alkynes, including aromatic alkynes, aliphatic alkynes, and ferrocene acetylene, can undergo the process successfully. The protocol provides a range of alkynyl-functionalized azaindoline scaffolds bearing a quarternary carbon center.
一种新型的钯催化的末端炔烃的串联环化/烷基化反应，在空气氛围条件下，成功地用于合成炔基官能化的 3,3-二取代的氮杂吲哚衍生物。各种类型的末端炔烃，包括芳香炔烃、脂肪族炔烃和二茂铁乙炔，都可以成功地进行这个过程。该方案提供了一系列带有季碳原子的炔基官能化的氮杂吲哚骨架。
