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CDC25C 是胰腺腺癌的一个预后生物标志物，与线粒体动态平衡相关。

CDC25C is a prognostic biomarker and correlated with mitochondrial homeostasis in pancreatic adenocarcinoma.

机构信息

Laboratory Medicine Center, Department of Clinical Laboratory, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, China.

Department of Central Laboratory, Affiliated Hangzhou first people's Hospital, Zhejiang University School of Medicine, Hangzhou, China.

出版信息

Bioengineered. 2022 May;13(5):13089-13107. doi: 10.1080/21655979.2022.2078940.

DOI:10.1080/21655979.2022.2078940
PMID:35615982
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9275923/
Abstract

Pancreatic adenocarcinoma (PAAD) is a common digestive tract malignant tumor with an extremely poor prognosis. The survival and prognosis may significantly improve if it is diagnosed early. Therefore, identifying biomarkers for early diagnosis is still considered a great clinical challenge in PAAD. Cell Division Cycle 25C (CDC25C), a cardinal cell cycle regulatory protein, directly mediates the G2/M phase and is intimately implicated in tumor development. In the current study, we aim to explore the possible functions of CDC25C and determine the potential role of CDC25C in the early diagnosis and prognosis of PAAD. Expression analysis indicated that CDC25C was overexpressed in PAAD . In addition, survival analysis revealed a strong correlation between the enhanced expression of CDC25C and poor survival in PAAD. Furthermore, pathway analysis showed that CDC25C is related to TP53 signaling pathways, glutathione metabolism, and glycolysis. Mechanically, our in vitro experiments verified that CDC25C was capable of promoting cell viability and proliferation. CDC25C inhibition increases the accumulation of ROS, inhibits mitochondrial respiration, suppresses glycolysis metabolism and reduces GSH levels. To summarize, CDC25C may be involved in energy metabolism by maintaining mitochondrial homeostasis. Our results suggested that CDC25C is a potential biological marker and promising therapeutic target of PAAD.

摘要

胰腺导管腺癌（PAAD）是一种常见的消化道恶性肿瘤，预后极差。如果能早期诊断，生存和预后可能会显著改善。因此，寻找用于早期诊断的生物标志物仍然是 PAAD 的一个重大临床挑战。细胞分裂周期蛋白 25C（CDC25C）是一种主要的细胞周期调节蛋白，直接介导 G2/M 期，与肿瘤的发生密切相关。在本研究中，我们旨在探讨 CDC25C 的可能功能，并确定 CDC25C 在 PAAD 早期诊断和预后中的潜在作用。表达分析表明，CDC25C 在 PAAD 中过表达。此外，生存分析显示，CDC25C 的表达增强与 PAAD 的不良预后之间存在强烈相关性。此外，通路分析表明，CDC25C 与 TP53 信号通路、谷胱甘肽代谢和糖酵解有关。从机制上讲，我们的体外实验验证了 CDC25C 能够促进细胞活力和增殖。CDC25C 抑制会增加 ROS 的积累，抑制线粒体呼吸，抑制糖酵解代谢并降低 GSH 水平。综上所述，CDC25C 可能通过维持线粒体稳态参与能量代谢。我们的研究结果表明，CDC25C 可能是 PAAD 的潜在生物标志物和有前途的治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bee5/9275923/4bd7cd1c131b/KBIE_A_2078940_F0011_B.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bee5/9275923/ca0dc6f6bc01/KBIE_A_2078940_F0007_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bee5/9275923/64907dfb6c76/KBIE_A_2078940_F0008_OC.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bee5/9275923/95f8e9cd200d/KBIE_A_2078940_F0010_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bee5/9275923/4bd7cd1c131b/KBIE_A_2078940_F0011_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bee5/9275923/64c7c6cc547b/KBIE_A_2078940_UF0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bee5/9275923/9f02dac5d7c7/KBIE_A_2078940_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bee5/9275923/438399e42017/KBIE_A_2078940_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bee5/9275923/a37d68efa5e8/KBIE_A_2078940_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bee5/9275923/aab4422894e2/KBIE_A_2078940_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bee5/9275923/5a4046e8cccc/KBIE_A_2078940_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bee5/9275923/62651770f898/KBIE_A_2078940_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bee5/9275923/ca0dc6f6bc01/KBIE_A_2078940_F0007_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bee5/9275923/64907dfb6c76/KBIE_A_2078940_F0008_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bee5/9275923/5a7412903742/KBIE_A_2078940_F0009_OC.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bee5/9275923/4bd7cd1c131b/KBIE_A_2078940_F0011_B.jpg

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