Assisted Reproduction Center, Northwest Women's and Children's Hospital, Xi'an, China.
School of Medicine, Southeast University, Nanjing, Jiangsu, China.
Cancer Rep (Hoboken). 2024 Jun;7(6):e2108. doi: 10.1002/cnr2.2108.
Pancreatic adenocarcinoma (PAAD), a member of highly lethal malignant tumors, has a poor outcome and extremely poor prognosis. The transient receptor potential (TRP) superfamily, a group of nonselective cation channels, is capable of influencing cellular functions by regulating calcium homeostasis. In addition, it has been shown that TRP channels can also affect various cellular phenotypes by regulating gene transcription levels and are involved in the development of a variety of malignant tumors.
In order to find new therapeutic targets and biomarkers to improve the clinical prognosis of pancreatic cancer, we performed genetic and immunological characterization of TRP channels in PAAD, as well as related functional and prognostic analyses.
We investigated the expression, genetic alterations, methylation levels, and immune infiltration levels of TRP channels in PAAD, and further also analyzed the function of TRP channels in PAAD and their prognostic value for PAAD patients. Our results suggest that TRPM8 may contribute to tumor proliferation by controlling the PI3K-AKT-mTOR signaling pathway in PAAD.
After careful evaluation of the accumulated data, we concluded that TRPM8 has potential as a prognostic indicator and prospective therapeutic target in PAAD.
胰腺导管腺癌（PAAD）是高度致命的恶性肿瘤之一，其预后极差。瞬时受体电位（TRP）超家族是一组非选择性阳离子通道，能够通过调节钙稳态来影响细胞功能。此外，已经表明 TRP 通道还可以通过调节基因转录水平来影响各种细胞表型，并参与多种恶性肿瘤的发生发展。
为了寻找新的治疗靶点和生物标志物来改善胰腺癌的临床预后，我们对 PAAD 中的 TRP 通道进行了遗传和免疫特征分析，并进行了相关的功能和预后分析。
我们研究了 TRP 通道在 PAAD 中的表达、遗传改变、甲基化水平和免疫浸润水平，并进一步分析了 TRP 通道在 PAAD 中的功能及其对 PAAD 患者的预后价值。我们的研究结果表明，TRPM8 可能通过控制 PI3K-AKT-mTOR 信号通路促进 PAAD 中的肿瘤增殖。
在仔细评估了积累的数据后，我们得出结论，TRPM8 可能成为 PAAD 中的一个有预后价值的指标和有前途的治疗靶点。
