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金黄色葡萄球菌感染的血液透析纽扣式移植物复合体,用万古霉素控制感染达11个月。

Staphylococcal epidermidis infection of a hemodialysis button-graft complex controlled by vancomycin for 11 months.

作者信息

Gault M H, Costerton J W, Paul M D, Parfrey P S, Purchase L H

出版信息

Nephron. 1987;45(2):126-8. doi: 10.1159/000184093.

DOI:10.1159/000184093
PMID:3561622
Abstract

A 54 year old woman had a Bentley DiaTAP button implanted in her thigh for hemodialysis access. She had been started on continuous ambulatory peritoneal dialysis (CAPD) because of intractable vascular access problems. Unfortunately, CAPD had to be discontinued because of fungal peritonitis. Transplantation had not been possible because of circulating cytotoxic antibodies. The prosthetic complex soon became infected with Staphylococcus epidermidis and blood cultures were intermittently positive for 11 months. However, with continuing vancomycin therapy she remained in her usual state of health, without side effects from vancomycin, until venous thrombosis resolved and it became possible to remove the infected prosthetic complex and implant a button in an arm. As a last resort, it may be possible to maintain a patient on dialysis in reasonable health with a DiaTAP button graft complex infected with Staphylococcus epidermidis and intermittent positive blood cultures using long term vancomycin therapy. Such management probably would not be appropriate for any other organism.

摘要

一名54岁女性在大腿植入了Bentley DiaTAP按钮用于血液透析通路。由于难以解决的血管通路问题,她开始接受持续性非卧床腹膜透析(CAPD)。不幸的是,由于真菌性腹膜炎,CAPD不得不停止。由于循环中的细胞毒性抗体,无法进行移植。人工合成物很快被表皮葡萄球菌感染,血培养在11个月内间歇性呈阳性。然而,持续使用万古霉素治疗期间,她保持了平常的健康状态,没有出现万古霉素的副作用,直到静脉血栓溶解,才得以移除感染的人工合成物并在手臂植入一个按钮。作为最后的手段,对于一名使用感染表皮葡萄球菌且血培养间歇性呈阳性的DiaTAP按钮移植物复合物的患者,使用长期万古霉素治疗可能可以使其维持在合理的健康状态进行透析。这种处理方法可能不适用于任何其他微生物。

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