Bosch J, Ponti R, Glabman S, Lauer A
Nephron. 1987;45(2):86-92. doi: 10.1159/000184085.
Three sets of experiments were performed to determine the effect of the dialysate sodium concentration on the sodium balance of patients undergoing maintenance hemodialysis. First, patients were treated with three different dialysate bath sodium concentrations: 125-132 mEq/l (n = 7), 135-140 mEq/l (n = 11) and 145-150 mEq/l (n = 6). We demonstrated that the pretreatment plasma sodium concentration was independent of the sodium concentration of the dialysate used. Second, the plasma sodium concentration available for diffusion during the treatment was calculated from the plasma sodium concentration and the plasma proteins. The accuracy of this calculation was demonstrated by comparing the predicted value with the concentration of sodium measured in an ultrafiltrate obtained at minimal filtration fraction. Third, the sodium fluxes using a hypernatremic or hyponatremic dialysate were calculated for 100 ml of plasma going through the dialyzer. At steady state, no significant differences in net sodium fluxes were demonstrated between hyper- and hyponatremic dialysis.
进行了三组实验，以确定透析液钠浓度对维持性血液透析患者钠平衡的影响。首先，用三种不同的透析液浴钠浓度治疗患者：125 - 132毫当量/升（n = 7）、135 - 140毫当量/升（n = 11）和145 - 150毫当量/升（n = 6）。我们证明，治疗前血浆钠浓度与所用透析液的钠浓度无关。其次，根据血浆钠浓度和血浆蛋白计算治疗期间可用于扩散的血浆钠浓度。通过将预测值与在最小滤过分数下获得的超滤液中测得的钠浓度进行比较，证明了该计算的准确性。第三，计算了100毫升通过透析器的血浆使用高钠或低钠透析液时的钠通量。在稳定状态下，高钠和低钠透析之间的净钠通量没有显著差异。
