Hosokawa S, Koike T, Kawaji A, Nishitani H, Nishio T, Tomoyoshi T, Sawanishi K, Yoshida O
Artif Organs. 1986 Feb;10(1):30-6. doi: 10.1111/j.1525-1594.1986.tb02513.x.
Zinc transfer during hemodialysis and plasma zinc concentrations in hemodialysis patients were examined. Fifteen volunteer outpatients undergoing hemodialysis showed significant increases in plasma zinc from 74.0 +/- 7.8 to 88.1 +/- 9.7 micrograms/dl after a 5-h dialysis. The increase was mainly the result of hemoconcentration as evidenced by a significant increase in the hematocrit and total serum protein during dialysis, but was also due to diffusion. To study the changes resulting from diffusion, zinc was measured in the arterial blood and in the dialysate at the inflow and outflow sites of the dialyzer. There was a significant (p less than 0.01) increase in the plasma zinc of the arterial blood from 74.7 +/- 8.1 to 80.2 +/- 6.5 micrograms/dl, but a nonsignificant decrease in the dialysate zinc from 10.6 +/- 2.5 to 9.5 +/- 5.9 micrograms/dl. Zinc diffused across the dialyzer from the dialysate to the blood in 12 cases and into the dialysate in three others.
对血液透析过程中的锌转运以及血液透析患者的血浆锌浓度进行了检测。15名接受血液透析的门诊志愿者在5小时透析后，血浆锌从74.0±7.8微克/分升显著增加至88.1±9.7微克/分升。这种增加主要是血液浓缩的结果，透析过程中血细胞比容和总血清蛋白显著增加证明了这一点，但也归因于扩散作用。为研究扩散引起的变化，在透析器的流入和流出部位对动脉血和透析液中的锌进行了测量。动脉血的血浆锌从74.7±8.1微克/分升显著增加（p＜0.01）至80.2±6.5微克/分升，而透析液锌从10.6±2.5微克/分升降至9.5±5.9微克/分升，差异不显著。12例中锌从透析液扩散至血液穿过透析器，另外3例则扩散至透析液中。
