Division of Cohort Research, National Cancer Center Institute for Cancer Control, Tokyo, Japan.
Health and Wellness Unit, African Population and Health Research Center, Nairobi, Kenya.
Int J Cancer. 2022 Oct 1;151(7):1068-1080. doi: 10.1002/ijc.34133. Epub 2022 Jun 8.
Sleep duration is emerging as an important modifiable risk factor for morbidity and mortality. We assessed the association between sleep duration and cancer incidence and mortality among Japanese adults using data from six population-based cohorts with 271 694 participants. During a total follow-up period of about 5.9 million person-years, we identified 40 751 incident cancer cases and 18 323 cancer deaths. We computed study-specific hazard ratios (HRs) and 95% confidence intervals (CIs) using Cox proportional hazards regression models and pooled the estimates using random-effects meta-analysis. Sleep duration of ≥10 hours (vs 7 hours) was associated with increased risk of cancer incidence among women (HR 1.19, 95% CI 1.02-1.38), but not men, and increased risk of cancer mortality among men (HR 1.18, 95% CI 1.00-1.39) and women (HR 1.44, 95% CI 1.20-1.73). Sleep duration of ≤5 hours (vs 7 hours) was not associated with cancer incidence and mortality. However, among postmenopausal women, sleep durations of both ≤5 and ≥10 hours (vs 7 hours) were associated with an increased risk of cancer mortality. Among Japanese adults, sleep duration of ≥10 hours is associated with increased risk of cancer incidence and mortality among women and cancer mortality among men.
睡眠时间正成为发病率和死亡率的一个重要可改变风险因素。我们利用来自六个基于人群的队列的参与者共 271694 人的数据，评估了睡眠时间与日本成年人癌症发病和死亡的相关性。在大约 590 万人年的总随访期间，我们发现了 40751 例癌症新发病例和 18323 例癌症死亡病例。我们使用 Cox 比例风险回归模型计算了特定研究的风险比（HR）和 95%置信区间（CI），并使用随机效应荟萃分析对估计值进行了汇总。与 7 小时睡眠时间相比，睡眠时间≥10 小时（vs. 7 小时）与女性癌症发病率增加相关（HR 1.19，95%CI 1.02-1.38），但与男性无关，与男性（HR 1.18，95%CI 1.00-1.39）和女性（HR 1.44，95%CI 1.20-1.73）癌症死亡率增加相关。睡眠时间≤5 小时与癌症发病率和死亡率无关。然而，对于绝经后女性，睡眠时间≤5 小时和≥10 小时（vs. 7 小时）均与癌症死亡率增加相关。在日本成年人中，睡眠时间≥10 小时与女性癌症发病率和死亡率增加以及男性癌症死亡率增加相关。
