Biswas Purbasha, Adebile Tolulope V, Sejoro Sarah, Liu Manyun, Zhang Xinyan, Tu Wei, Yu Lili
Jiann-Ping Hsu College of Public Health, Georgia Southern University, Statesboro, Georgia.
Boehringer Ingelheim, Gainesville, Georgia.
Sleep Biol Rhythms. 2024 Sep 3;23(1):55-65. doi: 10.1007/s41105-024-00551-y. eCollection 2025 Jan.
Epidemiologic research has demonstrated a connection between the duration of sleep and the risk of overall mortality. This research investigates the correlation between sleep duration (SD) and the likelihood of all-cause and cancer-specific mortality among cancer patients, exploring the association between SD and mortality risk. The study used the National Health Interview Survey (NHIS) data from 2004, a U.S.-based survey linked to a mortality database up to December 31, 2019. A total of 26,976 participants based on cancer responses, including 2082 cancer patients and 24,894 non-cancer patients, were included in this study. Participants self-reported SD (categorized as ≤ 5, 6, 7, 8, 9, or ≥ 10 h/day) was used. The Cox proportional hazards model for mortality risk was performed with demographic adjustments. Mortality risk was higher in adults with and without cancer and extremes (insufficient or more than sufficient) of SD. A J-shaped association was found between SD and all-cause and cancer-specific mortality risk among cancer and non-cancer patients. Among the cancer patients, compared with the reference group (7 h/day), both shorter and longer SDs were associated with increased risk of all-cause and cancer-specific mortality (≤ 5 h/day, HR 1.48 CI [1.77, 1.88]; 8 h/day, HR 1.45 CI [1.23, 1.72]; 9 h/day, HR 1.53 CI [1.18,1.99], ≥ 10 h/day, HR 2.15 CI [1.66, 2.78]); except the SD 6 h/day, HR 1.14 CI [0.93, 1.40]. The analysis included 349,936 person-years of observation. This study suggests that sleeping too long and too short is associated with increased risk among patients with all-cause and cancer-specific mortality.
流行病学研究表明，睡眠时间与全因死亡率风险之间存在关联。本研究调查了癌症患者的睡眠时间（SD）与全因死亡率和癌症特异性死亡率可能性之间的相关性，探讨了SD与死亡风险之间的关联。该研究使用了2004年美国国家健康访谈调查（NHIS）的数据，这是一项与截至2019年12月31日的死亡率数据库相关联的美国调查。本研究共纳入了26976名根据癌症反应的参与者，其中包括2082名癌症患者和24894名非癌症患者。参与者自我报告的SD（分为≤5、6、7、8、9或≥10小时/天）被采用。对死亡率风险进行了Cox比例风险模型的人口统计学调整。患有癌症和未患癌症的成年人以及SD极端情况（不足或过多）者的死亡风险更高。在癌症和非癌症患者中，发现SD与全因死亡率和癌症特异性死亡率风险之间呈J形关联。在癌症患者中，与参考组（7小时/天）相比，较短和较长的SD均与全因死亡率和癌症特异性死亡率风险增加相关（≤5小时/天，HR 1.48 CI[1.77, 1.88]；8小时/天，HR 1.45 CI[1.23, 1.72]；9小时/天，HR 1.53 CI[1.18, 1.99]，≥10小时/天，HR 2.15 CI[1.66, 2.78]）；除了6小时/天的SD，HR 1.14 CI[0.93, 1.40]。该分析包括349936人年的观察。这项研究表明，睡眠时间过长和过短都与全因死亡率和癌症特异性死亡率患者的风险增加有关。
