Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University, Uttar Pradesh, Sector-125, Noida, 201303, U.P., India.
Recent Pat Nanotechnol. 2023;17(4):284-306. doi: 10.2174/1872210516666220523121733.
The advent of technology provides a solution to various drug delivery-related problems by undertaking the development of a better drug delivery system, i.e., nano-sized drug delivery systems as they have shown huge prospects for effective delivery of drugs in the body. Nanostructured lipid carriers (NLCs) are such type of novel drug delivery system in which lipids of both solid and liquid types are used as a core for the disorganized matrix, which prevents the solid lipid crystallization and increases drug payload. They are generally composed of solid and liquid lipids, emulsifiers, drugs, and other various additives, which are selected based on purity, chemical stability, the concentration of materials required, compatibility, biodegradability, processing type, cost, and their regulatory status. Placing bioactives into nanostructured lipid carriers (NLCs) has enhanced pharmacokinetic characteristics by increasing therapeutic functionality and prolonging release from these carrier systems. In our opinion, the search involves two steps viz. fabrication strategies, production methods, and the impact of various types of substances on them, as well as the release mechanism and targeting modalities. In addition to other applications, the use of NLCs in gene therapy has marked a promising path for new and better drug delivery systems. Further development of various dosage forms using NLCs, like NLC based hydrogels, is being done for improving the overall aesthetic properties, leading to the desired therapeutic effect of the incorporated active. This review highlights several elements of NLCs, such as structural model and types, excipients utilized, factors affecting NLC production, preparation techniques, characterization, current applications, patents, challenges, and opportunities.
科技的进步为解决各种与药物输送相关的问题提供了一种解决方案，即开发更好的药物输送系统，例如纳米药物输送系统，因为它们在体内有效输送药物方面显示出巨大的前景。纳米结构脂质载体（NLCs）就是这样一种新型药物输送系统，其中固体和液体类型的脂质被用作无序基质的核心，这可以防止固体脂质结晶并增加药物载量。它们通常由固体和液体脂质、乳化剂、药物和其他各种添加剂组成，这些成分是根据纯度、化学稳定性、所需材料浓度、相容性、生物降解性、加工类型、成本和监管状况来选择的。将生物活性物质放入纳米结构脂质载体（NLCs）中，可以通过增加治疗功能并延长这些载体系统的释放时间来增强药物的药代动力学特性。在我们看来，这种搜索涉及两个步骤，即制造策略、生产方法以及各种物质对它们的影响，以及释放机制和靶向方式。除了其他应用，NLCs 在基因治疗中的应用为新型和更好的药物输送系统开辟了一条有希望的道路。正在使用 NLCs 开发各种剂型，如 NLC 基水凝胶，以改善整体美观性能，从而达到所包含活性物质的理想治疗效果。这篇综述强调了 NLCs 的几个要素，例如结构模型和类型、所用赋形剂、影响 NLC 生产的因素、制备技术、特性、当前应用、专利、挑战和机遇。
