Brodersen R, Stern L
Neuropediatrics. 1987 Feb;18(1):34-6. doi: 10.1055/s-2008-1052431.
In experimental work with bilirubin toxicity, incubates or injectates are prepared without added albumin, or with a molar excess of bilirubin over albumin. Bilirubin is liable to aggregation as free bilirubin acid under these circumstances, giving rise to variable toxicity. Stable solutions are obtained with a molar excess of albumin over bilirubin; such solutions show no toxicity, however. It is suggested that this difficulty may be circumvented by using an excess of albumin, adding a sulfonamide as a bilirubin displacer, to provoke toxicity.
在胆红素毒性的实验工作中，制备培养物或注射剂时不添加白蛋白，或者胆红素与白蛋白的摩尔比过量。在这些情况下，胆红素易于作为游离胆红素酸聚集，从而产生可变的毒性。当白蛋白与胆红素的摩尔比过量时可获得稳定的溶液；然而，这种溶液没有毒性。有人提出，可以通过使用过量的白蛋白，并添加一种磺胺类药物作为胆红素置换剂来引发毒性，从而规避这一难题。
