Department of Medicine, University of Cambridge, Addenbrookes Hospital, United Kingdom (E.F.W., X.L.).
Department of Cardiovascular Surgery, Zhongnan Hospital, Wuhan University School of Medicine, People's Republic of China (Y.L.).
Circ Res. 2022 May 27;130(11):1723-1741. doi: 10.1161/CIRCRESAHA.122.319808. Epub 2022 May 26.
Heart disease remains the leading cause of morbidity and mortality worldwide. With the advancement of modern technology, the role(s) of microtubules in the pathogenesis of heart disease has become increasingly apparent, though currently there are limited treatments targeting microtubule-relevant mechanisms. Here, we review the functions of microtubules in the cardiovascular system and their specific adaptive and pathological phenotypes in cardiac disorders. We further explore the use of microtubule-targeting drugs and highlight promising druggable therapeutic targets for the future treatment of heart diseases.
心脏病仍然是全世界发病率和死亡率的主要原因。随着现代技术的进步，微管在心脏病发病机制中的作用变得越来越明显，尽管目前针对微管相关机制的治疗方法有限。在这里，我们回顾了微管在心血管系统中的功能及其在心脏疾病中的特定适应性和病理性表型。我们进一步探讨了微管靶向药物的应用，并强调了未来治疗心脏病有前途的可药物治疗靶点。
