Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China.
Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China.
Int J Biochem Cell Biol. 2024 Oct;175:106650. doi: 10.1016/j.biocel.2024.106650. Epub 2024 Sep 3.
Microtubules, complex cytoskeletal structures composed of tubulin proteins in eukaryotic cells, have garnered recent attention in cardiovascular research. Investigations have focused on the post-translational modifications of tubulin, including acetylation and detyrosination. Perturbations in microtubule homeostasis have been implicated in various pathological processes associated with cardiovascular diseases such as heart failure, ischemic heart disease, and arrhythmias. Thus, elucidating the intricate interplay between microtubule dynamics and cardiovascular pathophysiology is imperative for advancing preventive and therapeutic strategies. Several natural compounds have been identified to potentially modulate microtubules, thereby exerting regulatory effects on cardiovascular diseases. This review synthesizes current literature to delineate the roles of microtubules in cardiovascular diseases and assesses the potential of natural compounds in microtubule-targeted therapies.
微管是真核细胞中由微管蛋白组成的复杂细胞骨架结构，近年来在心血管研究中受到关注。研究集中在微管蛋白的翻译后修饰上，包括乙酰化和去酪氨酸化。微管动态平衡的破坏与心力衰竭、缺血性心脏病和心律失常等心血管疾病相关的各种病理过程有关。因此，阐明微管动力学与心血管病理生理学之间的复杂相互作用对于推进预防和治疗策略至关重要。已经确定了几种天然化合物可能调节微管，从而对心血管疾病产生调节作用。本综述综合了当前的文献，阐述了微管在心血管疾病中的作用，并评估了天然化合物在微管靶向治疗中的潜力。
