Chokroverty S, Manocha M K, Duvoisin R C
Neurology. 1987 Apr;37(4):608-15. doi: 10.1212/wnl.37.4.608.
We report the physiologic and pharmacologic analysis in two women, aged 18 and 17 years, with essential myoclonus. Both responded to benztropine mesylate and had been functioning normally. The physiologic analysis suggested ballistic movement overflow and audiogenic stimulus-sensitive myoclonus. The pharmacologic study showed a direct and mutual antagonism of physostigmine and anticholinergic agent on myoclonus, implying cholinergic hyperactivity in the pathophysiology of myoclonus.
我们报告了两名年龄分别为18岁和17岁的特发性肌阵挛女性患者的生理和药理学分析。两人对甲磺酸苯扎托品均有反应，且此前功能正常。生理分析提示存在弹道运动溢流和听源性刺激敏感性肌阵挛。药理学研究表明毒扁豆碱和抗胆碱能药物对肌阵挛有直接的相互拮抗作用，这意味着胆碱能功能亢进在肌阵挛的病理生理学中起作用。
