Nutt J G
Neurology. 1983 Jul;33(7):932-5. doi: 10.1212/wnl.33.7.932.
The effects of centrally and peripherally active anti-cholinergic agents were investigated in four patients with Huntington's disease. Scopolamine reduced chorea, increased incoordination, induced sedation, and produced confusion. Benztropine produced similar but milder effects. A peripheral anticholinergic, glycopyrrolate, had no effect. These results, combined with previous studies, indicate that cholinergic agonists and antagonists that produce sedation may reduce chorea without improving coordination, and suggest that this antichoreic action is independent of their cholinergic actions.
对4例亨廷顿舞蹈症患者研究了中枢性和外周性抗胆碱能药物的作用。东莨菪碱减轻了舞蹈样动作，增加了共济失调，引起镇静，并导致意识模糊。苯海索产生了相似但较轻的作用。外周抗胆碱能药物格隆溴铵则无作用。这些结果与先前的研究相结合，表明能产生镇静作用的胆碱能激动剂和拮抗剂可能减轻舞蹈样动作而不改善共济失调，并提示这种抗舞蹈病作用与其胆碱能作用无关。
