Liu Tingting, Cheng Hui, Tian Li, Zhang Yueyue, Wang Shaotong, Lin Lu
The First Affiliated Hospital of Soochow University, Suzhou 215006, PR China.
School of Nursing, Medical College of Soochow University, Suzhou 215006, PR China.
Gen Hosp Psychiatry. 2022 Jul-Aug;77:118-127. doi: 10.1016/j.genhosppsych.2022.05.004. Epub 2022 May 18.
This meta-analysis was to critically evaluate the effects of aromatherapy on the symptoms of anxiety and depression in cancer patients.
Eight Chinese and English databases (CNKI, Wanfang, VIP, CBM, Cochrane Library, PubMed, Embase, and PsycINFO) were systematically searched from the inception of databases to October 2021 for randomized controlled trials (RCTs). According to Cochrane Collaboration criteria, two reviewers independently assessed the risk of bias and extract data from included studies. All analyses were performed with Review Manager 5.4.
Eleven qualified studies were included in the meta-analysis, ten of which reported the effect of aromatherapy on anxiety in cancer patients, including 1724 patients; five of the studies reported the effect on depression, including 1039 patients. The quality of the included studies was low, and most studies compared aromatherapy to usual care. This meta-analysis indicated that aromatherapy appeared to be effective for anxiety [SMD = -0.51, 95%CI (-0.83, -0.19), P = 0.002] and depression [SMD = -0.44, 95%CI (-0.76, -0.12), P = 0.008] symptoms in cancer patients. Inhalation aromatherapy may be more effective than massage. Aromatherapy seemed to improve the anxiety symptoms in cancer patients in a short time, especially in perioperative patients, but had no effect for patients treated with radiation, chemotherapy or palliative therapy. Placebo also appeared to be effective in some studies.
Aromatherapy, especially inhalation aromatherapy, may help relieve symptoms of anxiety and depression in cancer patients, but more and higher-quality studies are needed. The literature does not yet support clinical implementation.
本荟萃分析旨在严格评估芳香疗法对癌症患者焦虑和抑郁症状的影响。
从数据库建立至2021年10月，系统检索了8个中英文数据库（中国知网、万方、维普、中国生物医学文献数据库、考克兰图书馆、PubMed、Embase和PsycINFO），以查找随机对照试验（RCT）。根据考克兰协作网标准，两名评价员独立评估偏倚风险并从纳入研究中提取数据。所有分析均使用Review Manager 5.4进行。
11项合格研究纳入荟萃分析，其中10项报告了芳香疗法对癌症患者焦虑的影响，涉及1724例患者；5项研究报告了对抑郁的影响，涉及1039例患者。纳入研究的质量较低，大多数研究将芳香疗法与常规护理进行比较。本荟萃分析表明，芳香疗法似乎对癌症患者的焦虑[标准化均数差（SMD）=-0.51，95%置信区间（CI）（-0.83，-0.19），P=0.002]和抑郁[SMD=-0.44，95%CI（-0.76，-0.12），P=0.008]症状有效。吸入式芳香疗法可能比按摩更有效。芳香疗法似乎能在短时间内改善癌症患者的焦虑症状，尤其是围手术期患者，但对接受放疗、化疗或姑息治疗的患者无效。在一些研究中，安慰剂似乎也有效。
芳香疗法，尤其是吸入式芳香疗法，可能有助于缓解癌症患者的焦虑和抑郁症状，但需要更多更高质量的研究。目前的文献尚不支持临床应用。
