Department of Psychology, University of Milano-Bicocca, Milan, Italy
Department of Adult Psychiatry, Nimes University Hospital, Nimes, France.
BMJ Open. 2022 May 26;12(5):e056492. doi: 10.1136/bmjopen-2021-056492.
Prevalence of suicidal thoughts and behaviours is higher among patients with borderline personality disorder than the general population. However, evidence concerning the role of specific borderline symptoms for predicting suicide-related outcomes is lacking and no systematic review/meta-analysis (SR/MA) investigated this topic. Our aim will be to investigate the relationship between any borderline symptom (except criterion 5) and suicide-related outcomes both through an SR/MA and an individual patient data meta-analysis (IPD-MA).
We will search PubMed/MEDLINE, Scopus, Web of Science, Embase, PsycINFO, CINAHL and Cochrane Library databases from 1974 until September 2021. Both published and unpublished studies showing the association between any borderline symptom (except criterion 5) and suicide-related outcomes (death wish, suicidal ideation, suicidal plan, non-suicidal self-injury, deliberate self-harm, suicide attempt, suicidal behaviour disorder, suicide) will be included. Two team members will independently perform the selection of the studies and data extraction, with the supervision of two other members in case of discrepancies; and assess each study with study quality assessment tools by National Institutes of Health and Grading of Recommendations Assessment, Development and Evaluation. Each author will be contacted. If possible, we will perform both random-effect meta-analyses on the collected data (odds, risk, rate ratios or correlations) and an IPD-MA on collected databases.
This study does not require an ethical approval. Results will be publicly disseminated, included in research presentations and published in peer-review journals.
CRD42018078696.
边缘型人格障碍患者的自杀念头和行为比一般人群更为常见。然而，对于特定边缘型人格障碍症状预测自杀相关结局的作用，目前尚缺乏相关证据，也没有系统综述/荟萃分析（SR/MA）对此进行研究。我们的目的是通过 SR/MA 和个体患者数据荟萃分析（IPD-MA）来研究任何边缘型人格障碍症状（除了第 5 项标准）与自杀相关结局之间的关系。
我们将检索 1974 年至 2021 年 9 月期间的 PubMed/MEDLINE、Scopus、Web of Science、Embase、PsycINFO、CINAHL 和 Cochrane Library 数据库。将纳入显示任何边缘型人格障碍症状（除了第 5 项标准）与自杀相关结局（死亡意愿、自杀意念、自杀计划、非自杀性自伤、故意自我伤害、自杀企图、自杀行为障碍、自杀）之间关联的已发表和未发表的研究。两名团队成员将独立进行研究选择和数据提取，如有差异，将由另外两名成员进行监督；并使用 NIH 研究质量评估工具和推荐评估、制定和评估分级系统（Grading of Recommendations Assessment, Development and Evaluation）评估每一项研究。将与每位作者联系。如有可能，我们将对收集的数据进行随机效应荟萃分析（比值比、风险比、率比或相关性），并对收集的数据库进行 IPD-MA。
本研究不需要伦理批准。研究结果将公开传播，包括在研究报告中，并发表在同行评议期刊上。
PROSPERO 注册号：CRD42018078696。
