奥密克戎 BA.1 对 BA.2 和 BA.3 SARS-CoV-2 的交叉中和作用。
Cross-neutralization of Omicron BA.1 against BA.2 and BA.3 SARS-CoV-2.
机构信息
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.
Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA.
出版信息
Nat Commun. 2022 May 26;13(1):2956. doi: 10.1038/s41467-022-30580-5.
The Omicron SARS-CoV-2 has several distinct sublineages, among which sublineage BA.1 is responsible for the initial Omicron surge and is now being replaced by BA.2 worldwide, whereas BA.3 is currently at a low frequency. The ongoing BA.1-to-BA.2 replacement underscores the importance to understand the cross-neutralization among the three Omicron sublineages. Here we test the neutralization of BA.1-infected human sera against BA.2, BA.3, and USA/WA1-2020 (a strain isolated in late January 2020). The BA.1-infected sera neutralize BA.1, BA.2, BA.3, and USA/WA1-2020 SARS-CoV-2s with geometric mean titers (GMTs) of 445, 107, 102, and 16, respectively. Thus, the neutralizing GMTs against heterologous BA.2, BA.3, and USA/WA1-2020 are 4.2-, 4.4-, and 28.4-fold lower than the GMT against homologous BA.1, respectively. These findings have implications in COVID-19 vaccine strategy.
奥密克戎 SARS-CoV-2 有几个不同的亚谱系，其中亚谱系 BA.1 是最初奥密克戎浪潮的罪魁祸首，现在正在全球范围内被 BA.2 取代，而 BA.3 目前频率较低。正在进行的 BA.1 到 BA.2 的取代强调了理解三种奥密克戎亚谱系之间交叉中和的重要性。在这里，我们测试了 BA.1 感染的人类血清对 BA.2、BA.3 和 USA/WA1-2020（2020 年 1 月下旬分离的菌株）的中和作用。BA.1 感染的血清对 BA.1、BA.2、BA.3 和 USA/WA1-2020 SARS-CoV-2 的中和几何平均滴度（GMT）分别为 445、107、102 和 16。因此，针对异源 BA.2、BA.3 和 USA/WA1-2020 的中和 GMT 分别比同源 BA.1 的 GMT 低 4.2、4.4 和 28.4 倍。这些发现对 COVID-19 疫苗策略有影响。
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