Carmody J, Cooper K
Neurosci Lett. 1987 Mar 9;74(3):358-63. doi: 10.1016/0304-3940(87)90324-7.
Chronic nociception has been studied in male mice by means of the formalin test in which forelimb motor behaviour is scored after subcutaneous formalin injection. The rating remained above 2.0 for 30 min after the injection (scale range 0-3). The magnitude of the nociception has been compared with that reported in other animal types. Mice are more sensitive than rats, cats and monkeys. The stress of a swim of 3 min has been found to reduce nociception by up to 25%. This analgesia is wholly opioid in nature, being abolished by a moderate dose of naloxone (1 mg/kg).
通过福尔马林试验对雄性小鼠的慢性伤害感受进行了研究，该试验是在皮下注射福尔马林后对前肢运动行为进行评分。注射后30分钟内评分保持在2.0以上（评分范围0 - 3）。已将这种伤害感受的程度与其他动物类型的报告进行了比较。小鼠比大鼠、猫和猴子更敏感。已发现3分钟游泳应激可使伤害感受降低多达25%。这种镇痛作用本质上完全是阿片类的，中等剂量的纳洛酮（1毫克/千克）可消除这种作用。
