Marek P, Panocka I, Sadowski B
Institute of Genetics and Animal Breeding, Department of Behavioral Physiology, Polish Academy of Sciences, Jastrzebiec, 05-551 MrokówPoland.
Pain. 1987 Jun;29(3):393-398. doi: 10.1016/0304-3959(87)90054-6.
Selective breeding of mice displaying high and low swim-induced analgesia led to the development of two animal lines divergent in the magnitude of analgesic response to swimming. In this study, animals belonging to the seventh generation of both lines were exposed to two temporally different forms of footshock, one of which produced opioid and the other non-opioid analgesia. We found that selective breeding for high and low swim-induced analgesia exerted a striking influence on the magnitude of the opioid-mediated type of footshock analgesia, but was ineffective on that of the non-opioid type.
对表现出高和低游泳诱导镇痛的小鼠进行选择性育种，导致培育出了两个品系的动物，它们对游泳的镇痛反应程度存在差异。在本研究中，这两个品系第七代的动物接受了两种时间上不同形式的足部电击，其中一种产生阿片类镇痛，另一种产生非阿片类镇痛。我们发现，对高和低游泳诱导镇痛进行的选择性育种对阿片类介导的足部电击镇痛的程度产生了显著影响，但对非阿片类类型的镇痛程度没有效果。
