Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA.
Division of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, CA, USA.
Methods Mol Biol. 2022;2485:99-109. doi: 10.1007/978-1-0716-2261-2_7.
Microelectrode array (MEA) is an electrophysiological instrument used to track activities of ion channels in excitable cells. Neurons and cardiomyocytes are seeded to form a cell monolayer on a field of sensors able to detect electrical signals, called extracellular field potentials (EFPs). This noninvasive tool allows researchers to investigate key parameters such as EFP amplitude, duration, and arrhythmias. MEA is progressively considered the gold standard for high-throughput in vitro electrophysiological evaluation, particularly for cardiac disease modeling and cardiac toxicity assessment.
微电极阵列 (MEA) 是一种用于跟踪可兴奋细胞中离子通道活动的电生理学仪器。神经元和心肌细胞被播种到能够检测电信号的传感器场形成细胞单层，称为细胞外场电位 (EFP)。这种非侵入性工具使研究人员能够研究关键参数，如 EFP 幅度、持续时间和心律失常。MEA 逐渐被认为是高通量体外电生理评估的金标准，特别是在心脏疾病建模和心脏毒性评估方面。
