A. P. Avtsyn Research Institute of Human Morphology, Moscow, Russia.
Bull Exp Biol Med. 2022 May;173(1):110-113. doi: 10.1007/s10517-022-05503-5. Epub 2022 May 27.
We studied the mechanisms underlying decreased production of epinephrine by adrenal glands in rats developmentally exposed to endocrine disruptor DDT was performed on the basis of assessment of morphology, fine structure, and function of the adrenal medulla and medullary cells. It was found that the main mechanisms of disruptive action of DDT leading to a decrease in epinephrine secretion into systemic circulation are a decrease in the growth rate of the adrenal medulla, a decrease in the number of mitochondria in adrenal cells, especially under the outer cytoplasmic membrane, destructive changes in mitochondria, and a progressive decrease in the synthesis of tyrosine hydroxylase. The decrease in the number of mitochondria and suppression tyrosine hydroxylase synthesis in adrenal cells predominate during the pubertal period, while slowdown of the growth of the adrenal medulla and progressive decrease in the synthesis of tyrosine hydroxylase seem to be the most evident mechanisms after puberty.
我们研究了在发育过程中暴露于内分泌干扰物滴滴涕的大鼠肾上腺中肾上腺素产生减少的机制，这是基于对肾上腺髓质和髓质细胞的形态、精细结构和功能的评估进行的。研究发现，滴滴涕导致肾上腺素分泌到体循环减少的主要破坏作用机制是肾上腺皮质生长速度减慢，肾上腺细胞中线粒体数量减少，特别是在外质膜下，线粒体发生破坏性变化，酪氨酸羟化酶的合成逐渐减少。在青春期，肾上腺细胞中线粒体数量减少和酪氨酸羟化酶合成受到抑制占主导地位，而肾上腺皮质生长速度减慢和酪氨酸羟化酶合成逐渐减少似乎是青春期后的最明显机制。
