Division of Nephrology, University Health Network, Toronto, ON, Canada.
Ajmera Transplant Centre, University Health Network, Toronto, ON, Canada.
Front Immunol. 2022 May 10;13:879200. doi: 10.3389/fimmu.2022.879200. eCollection 2022.
Clinical research is about asking and answering questions. Before solutions relevant to clinical problems can be sought, clinicians must frame questions in ways that are answerable using the methods of clinical research. Different types of questions are best answered using specific study designs. Each design has inherent strengths and limitations. In this review article, we provide an approach to asking answerable clinical research questions, review the major study designs, describe their strengths and weaknesses, and link the study designs to their intended purposes.
临床研究就是提出并回答问题。在寻求与临床问题相关的解决方案之前，临床医生必须以能够通过临床研究方法回答的方式提出问题。不同类型的问题最好使用特定的研究设计来回答。每种设计都有其固有的优势和局限性。在这篇综述文章中，我们提供了一种提出可回答的临床研究问题的方法，回顾了主要的研究设计，描述了它们的优缺点，并将研究设计与其预期目的联系起来。
