Regeneration of β cells from cell phenotype conversion among the pancreatic endocrine cells.
作者信息
Wei Tianjiao, Wei Rui, Hong Tianpei
机构信息
Department of Endocrinology and Metabolism Peking University Third Hospital Beijing 100191 China.
出版信息
Chronic Dis Transl Med. 2022 Mar 2;8(1):1-4. doi: 10.1002/cdt3.15. eCollection 2022 Mar.
Abstract
摘要
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Mesenchymal stem cell-derived exosomal miR-146a reverses diabetic β-cell dedifferentiation.间充质干细胞来源的外泌体 miR-146a 逆转糖尿病 β 细胞去分化。
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Pancreatic Ppy-expressing γ-cells display mixed phenotypic traits and the adaptive plasticity to engage insulin production.表达胰淀素的 γ 细胞表现出混合的表型特征，并具有参与胰岛素产生的适应性可塑性。
Nat Commun. 2021 Jul 22;12(1):4458. doi: 10.1038/s41467-021-24788-0.
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Pre-existing beta cells but not progenitors contribute to new beta cells in the adult pancreas.成年胰腺中，已有的β细胞而非祖细胞对新的β细胞有贡献。
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