Ozturk Alpaslan
Department of Medical Biochemistry, Amasya University Faculty of Medicine, Amasya 05100, Turkey.
Mol Clin Oncol. 2022 Jun;16(6):111. doi: 10.3892/mco.2022.2544. Epub 2022 May 12.
Annexins are a large group of proteins occurring in numerous cell types. Annexins have roles in events such as coagulation inhibition, endocytosis, exocytosis, signal transduction, proliferation and programmed cell death. The association of annexins with numerous diseases has been reported. There are 12 annexin proteins in total and the association of annexin A3 (ANXA3) with numerous malignant tumor types, such as breast cancer, prostate cancer, lung cancer, stomach cancer and colon cancer, has been reported. Studies investigating the relationship between ANXA3 and breast cancer were analyzed in the present review and it was observed that ANXA3 is expressed at higher levels in breast cancer cells. Furthermore, high ANXA3 levels are a poor prognostic factor, increase the invasion ability of breast cancer cells and may be a novel therapeutic target.
膜联蛋白是一大类存在于多种细胞类型中的蛋白质。膜联蛋白在诸如凝血抑制、胞吞作用、胞吐作用、信号转导、增殖和程序性细胞死亡等过程中发挥作用。已有报道膜联蛋白与多种疾病相关。膜联蛋白共有12种，其中膜联蛋白A3（ANXA3）已被报道与多种恶性肿瘤类型相关，如乳腺癌、前列腺癌、肺癌、胃癌和结肠癌。本综述分析了关于ANXA3与乳腺癌关系的研究，发现ANXA3在乳腺癌细胞中表达水平较高。此外，高ANXA3水平是一个不良预后因素，会增加乳腺癌细胞的侵袭能力，可能是一个新的治疗靶点。
