Department of Biochemistry and Molecular Biology, School of Life Sciences, Shahjalal University of Science and Technology, Sylhet, 3114, Bangladesh.
Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, Brisbane, QLD, 4072, Australia.
Small. 2022 Jul;18(26):e2107571. doi: 10.1002/smll.202107571. Epub 2022 May 27.
The integration of nanoarchitectonics and hydrogel into conventional biosensing platforms offers the opportunities to design physically and chemically controlled and optimized soft structures with superior biocompatibility, better immobilization of biomolecules, and specific and sensitive biosensor design. The physical and chemical properties of 3D hydrogel structures can be modified by integrating with nanostructures. Such modifications can enhance their responsiveness to mechanical, optical, thermal, magnetic, and electric stimuli, which in turn can enhance the practicality of biosensors in clinical settings. This review describes the synthesis and kinetics of gel networks and exploitation of nanostructure-integrated hydrogels in biosensing. With an emphasis on different integration strategies of hydrogel with nanostructures, this review highlights the importance of hydrogel nanostructures as one of the most favorable candidates for developing ultrasensitive biosensors. Moreover, hydrogel nanoarchitectonics are also portrayed as a promising candidate for fabricating next-generation robust biosensors.
将纳米结构和水凝胶整合到传统的生物传感平台中，为设计具有优越生物相容性、更好的生物分子固定化和特定敏感生物传感器设计的物理和化学控制及优化的软结构提供了机会。通过与纳米结构集成，可以改变 3D 水凝胶结构的物理和化学性质。这种修饰可以增强它们对机械、光学、热、磁和电刺激的响应能力，从而可以提高生物传感器在临床环境中的实用性。本文综述了凝胶网络的合成和动力学以及纳米结构集成水凝胶在生物传感中的应用。本文重点介绍了水凝胶与纳米结构的不同集成策略，强调了水凝胶纳米结构作为开发超灵敏生物传感器的最有前途的候选材料之一的重要性。此外，水凝胶纳米结构也被描绘为制造下一代坚固耐用的生物传感器的有前途的候选材料。
