From the Departments of Paediatrics.
Surgery, University of Otago Christchurch, Christchurch, New Zealand.
J Pediatr Gastroenterol Nutr. 2022 Jul 1;75(1):48-51. doi: 10.1097/MPG.0000000000003477. Epub 2022 May 27.
Although chitinase-3-like-1 (CHI3L1), predominately produced by epithelial cells and macrophages, is relevant to pulmonary disease in cystic fibrosis (CF), fecal levels have not yet been assessed in children with CF. Fecal CHI3L1 was measured with a commercial immunoassay using fecal samples provided by children with CF and healthy control (HC) children. Higher median (interquartile range) fecal CHI3L1 levels were seen in the 52 children with CF than in the 35 controls: 15.97 (3.34-50.53) ng/g versus 2.93 (2.13-9.27) ng/g ( P = 0.001). Fecal CHI3LI did not differ according to sex. In the children with CF, fecal CHI3L1 levels did not correlate with growth parameters nor were the levels affected by pancreatic insufficiency. Children with CF had higher fecal CHI3L1 levels, suggesting underlying gut inflammation. Further work is required to confirm the current findings and to ascertain the longer-term significance of elevated CHI3L1.
虽然几丁质酶 3 样蛋白 1（CHI3L1）主要由上皮细胞和巨噬细胞产生，与囊性纤维化（CF）中的肺部疾病有关，但 CF 儿童的粪便水平尚未得到评估。使用商业免疫测定法测量了 CF 儿童和健康对照（HC）儿童提供的粪便样本中的粪便 CHI3L1。52 名 CF 儿童的中位（四分位距）粪便 CHI3L1 水平高于 35 名对照者：15.97（3.34-50.53）ng/g 与 2.93（2.13-9.27）ng/g（P=0.001）。粪便 CHI3LI 与性别无关。在 CF 儿童中，粪便 CHI3L1 水平与生长参数无关，胰腺功能不全也不会影响其水平。CF 儿童的粪便 CHI3L1 水平较高，提示存在肠道炎症。需要进一步研究来证实目前的发现，并确定升高的 CHI3L1 的长期意义。
