Pham-Thanh Long, Nguyen-Tien Thang, Magnusson Ulf, Bui Vuong Nghia, Bui Anh Ngoc, Lundkvist Åke, Vu Duoc Trong, Tran Son Hai, Can Minh Xuan, Nguyen-Viet Hung, Lindahl Johanna F
International Livestock Research Institute (ILRI), Hanoi 10000, Vietnam.
Department of Medical Biochemistry and Microbiology, Uppsala University, 75123 Uppsala, Sweden.
Trop Med Infect Dis. 2022 May 19;7(5):79. doi: 10.3390/tropicalmed7050079.
Mosquito-borne diseases (MBDs), including those caused by flaviviruses, remain human health problems for developing and urbanizing economies. This cross-sectional study examined risks of flavivirus exposure through a survey regarding knowledge and practices of pig farmers, and serological analysis of pigs in peri-urban and suburban Hanoi city. A total of 636 pig sera from 179 pig farms in 4 districts, namely, Chuong My, Dan Phuong, Ha Dong, and Bac Tu Liem, were analyzed by a competitive ELISA designed for flavivirus antibody detection. The results indicated a low level of awareness about MBDs among pig farmers, and a high seroprevalence in pigs at 88.5% (95%CI = 85.8-90.9%). Moreover, common practices of pig owners to prevent mosquitoes at home and farm did not show a significant reduction in flavivirus exposure in pigs. At animal level, significant associations between seropositive pigs and the farms with more than 60 pigs, and the district location were found. Farm-level multivariable analysis did not identify significant risk factors for flavivirus exposure. The study suggests that improving awareness of pig owners about MBDs in Hanoi city may be warranted to reduce the risk for MBD flavivirus infections in both humans and pigs.
包括由黄病毒引起的疾病在内，蚊媒疾病（MBDs）仍然是发展中经济体和城市化经济体面临的人类健康问题。这项横断面研究通过对养猪户的知识和行为进行调查以及对河内市城郊和郊区猪的血清学分析，来研究黄病毒暴露风险。对来自常美、丹凤、河东和北慈廉4个区179个养猪场的636份猪血清，采用专为检测黄病毒抗体设计的竞争性酶联免疫吸附测定（ELISA）进行分析。结果表明，养猪户对蚊媒疾病的认知水平较低，猪的血清阳性率较高，为88.5%（95%置信区间=85.8 - 90.9%）。此外，养猪户在家中和农场预防蚊子的常见做法并未显著降低猪的黄病毒暴露风险。在动物层面，发现血清阳性猪与猪只数量超过60头的农场以及地区位置之间存在显著关联。农场层面的多变量分析未确定黄病毒暴露的显著风险因素。该研究表明，提高河内市养猪户对蚊媒疾病的认识，可能有助于降低人类和猪感染黄病毒蚊媒疾病的风险。
