富含 Sn-2 棕榈酸酯配方喂养对婴儿生长、粪便特征、粪便脂肪酸皂含量和骨矿物质含量的影响：系统评价和随机对照试验的荟萃分析。

Effects of Sn-2-palmitate-enriched formula feeding on infants' growth, stool characteristics, stool fatty acid soap contents and bone mineral content: A systematic review and meta-analysis of randomized controlled trials.

机构信息

Department of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China.

CNS Academy of Nutrition and Health, Chinese Nutrition Society, Beijing, China.

出版信息

Crit Rev Food Sci Nutr. 2023;63(30):10256-10266. doi: 10.1080/10408398.2022.2079606. Epub 2022 May 27.

DOI:10.1080/10408398.2022.2079606

PMID:35622955

Abstract

This systematic review and meta-analysis was performed to assess the effects of Sn-2-palmitate-enriched formula feeding on infants' growth, stool characteristics, stool fatty acid (FA) soap contents and bone mineral content (BMC). We searched PubMed, MEDLINE, Embase and Web of Science for randomized controlled trials published up to April 2022. Sixteen studies involving 1,931 infants were included. From each included study, weighted mean differences (WMDs) and 95% confidence intervals (CIs) for each of the above mentioned outcomes were extracted and pooled with a fixed-effects model ( ≤ 50%) or a random-effects model ( > 50%). Infants fed Sn-2-palmitate-enriched formula exhibited greater weight gains (WMD: 0.81; 95% CI: 0.23, 1.39 g/d; = 0.00%), lower contents of total stool FA soaps (WMD: -3.47; 95% CI: -5.08, -1.86 mg/100 mg; = 0.00%) and higher BMC (WMD: 7.08; 95% CI: 4.05, 10.10; = 0.00%) than infants fed standard formula. However, no difference was observed in these outcomes between infants fed Sn-2-palmitate-enriched formula and those fed human milk. This meta-analysis demonstrated that compared with standard formula feeding, Sn-2-palmitate-enriched formula feeding could effectively promote weight gains, bone mineral accumulation and stool FA soap reduction in infants.

摘要

本系统评价和荟萃分析旨在评估富含 Sn-2-棕榈酸酯的配方奶喂养对婴儿生长、粪便特征、粪便脂肪酸（FA）皂含量和骨矿物质含量（BMC）的影响。我们检索了 PubMed、MEDLINE、Embase 和 Web of Science 中截至 2022 年 4 月发表的随机对照试验。纳入了 1931 名婴儿的 16 项研究。从每个纳入的研究中，提取了上述每个结局的加权均数差（WMD）和 95%置信区间（CI），并采用固定效应模型（≤50%）或随机效应模型（>50%）进行汇总。与标准配方奶喂养相比，富含 Sn-2-棕榈酸酯的配方奶喂养的婴儿体重增加更多（WMD：0.81；95%CI：0.23，1.39 g/d； = 0.00），粪便总 FA 皂含量更低（WMD：-3.47；95%CI：-5.08，-1.86 mg/100 mg； = 0.00），BMC 更高（WMD：7.08；95%CI：4.05，10.10； = 0.00）。然而，富含 Sn-2-棕榈酸酯的配方奶喂养与母乳喂养的婴儿在这些结局上没有差异。本荟萃分析表明，与标准配方奶喂养相比，富含 Sn-2-棕榈酸酯的配方奶喂养可有效促进婴儿体重增加、骨矿物质积累和粪便 FA 皂减少。