Department of Microbiology, Faculty of Basic and Applied Sciences, Osun State University, Osogbo 230212, Osun State, Nigeria; Key Laboratory of Special Pathogens and Biosafety, Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, Hubei, China; International College, University of Chinese Academy of Sciences, Beijing, China; Organization of African Academic Doctors, Off Kamiti Road, P.O. Box 25305-00100, Nairobi, Kenya.
Department of Microbiology, Faculty of Basic and Applied Sciences, Osun State University, Osogbo 230212, Osun State, Nigeria; Organization of African Academic Doctors, Off Kamiti Road, P.O. Box 25305-00100, Nairobi, Kenya.
Microbiol Res. 2022 Aug;261:127069. doi: 10.1016/j.micres.2022.127069. Epub 2022 May 13.
Acinetobacter baumannii is an important nosocomial and opportunistic pathogen. It causes infections worldwide, especially in intensive care units. It is clinically significant owing to its ability to persist for long periods on surfaces, as well as its resistance to multiple antibiotics. This pathogen has been reported to defy the available therapeutic options to combat it. In this dire circumstance, the need for new approaches to treating A. baumannii infections is undeniable. In this minireview, we summarize three important treatment options for controlling A. baumannii pathogen, including the use of bacteriophage / bacteriophage cocktails, phage-antibiotic combinations and resistance-driven fitness losses. It is hoped that, as resources to treat its infection expand, A. baumannii can become less scary.
鲍曼不动杆菌是一种重要的医院获得性和机会性病原体。它在世界各地引起感染，尤其是在重症监护病房。由于其能够在表面长时间存活以及对多种抗生素的耐药性，因此具有临床意义。据报道，这种病原体已经对现有的治疗方法产生了抗药性。在这种严峻的情况下，需要寻找新的方法来治疗鲍曼不动杆菌感染。在这篇简短的综述中，我们总结了控制鲍曼不动杆菌病原体的三种重要治疗方法，包括使用噬菌体/噬菌体鸡尾酒、噬菌体-抗生素组合和耐药性驱动的适应性损失。希望随着治疗感染的资源的增加，鲍曼不动杆菌能够变得不那么可怕。
