Liang Zhongzhi, Tian Di, Huang Yanlan, Dou Shanjiang, Yang Anxin, Chen Zuyi
Department of Laboratory Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Department of Medical Laboratory, Qianxi People's Hospital, Qianxi, Guizhou, China.
Front Public Health. 2025 Jul 3;13:1592783. doi: 10.3389/fpubh.2025.1592783. eCollection 2025.
The widely prevalent is a gram-negative opportunistic pathogen, with the enormous potential to trigger multiple concurrent diseases. Due to its multidrug resistance, has emerged as a key monitored pathogen of WHO for surveillance in healthcare settings, particularly in intensive care units (ICUs).
To identify factors associated with infection in Guizhou province, China from 2015 to 2023, a retrospective cross-sectional analysis was carried out with the data from hospital records, electronic medical databases. Fisher's exact test (gender) and Chi-square were used for statistical tests, while -values was used to define the statistically significance of variables.
Out of 460,620 patients; there were 6,944 positive infection events, with ICU-related infections accounting for 45.77%. Males had a significantly higher risk of infection compared to females, and host factors such as gender and increasing age were associated with greater susceptibility. In addition, infection rates were higher during warmer summer months, suggesting a possible seasonal trend in transmission. Within the population undergoing antibiotic therapy, only polymyxin B demonstrated an alarmingly high level of resistance, whereas other clinically employed antibiotics were invalid. In summary, the statistical data from these years emphasizes that gender and age are main drivers of outbreaks in Guizhou, and follow-up public health interventions need to target these factors to enhance infection control and reduce the spread. Also, the observation of high levels of resistance to multiple antibiotics is a matter of concern, as it presents significant challenges in terms of treatment.
[病原体名称]是一种广泛流行的革兰氏阴性机会致病菌，极有可能引发多种并发疾病。由于其具有多重耐药性，已成为世界卫生组织在医疗机构，尤其是重症监护病房（ICU）中重点监测的病原体。
为确定2015年至2023年中国贵州省与[病原体名称]感染相关的因素，利用医院记录、电子医疗数据库中的数据进行回顾性横断面分析。采用Fisher精确检验（性别）和卡方检验进行统计分析，用P值确定变量的统计学意义。
在460,620例患者中，有6,944例[病原体名称]感染阳性事件，其中与ICU相关的感染占45.77%。男性感染[病原体名称]的风险显著高于女性，性别和年龄增长等宿主因素与易感性增加有关。此外，夏季感染率较高，表明传播可能存在季节性趋势。在接受抗生素治疗的人群中，只有多粘菌素B显示出极高的耐药水平，而其他临床使用的抗生素均无效。总之，这些年的统计数据表明，性别和年龄是贵州省[病原体名称]暴发的主要驱动因素，后续的公共卫生干预措施需要针对这些因素，以加强感染控制并减少传播。此外，对多种抗生素的高耐药性观察令人担忧，因为这在治疗方面带来了重大挑战。
