Human Oncology and Pathogenesis Program and Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Nat Cancer. 2022 May;3(5):536-546. doi: 10.1038/s43018-022-00384-z. Epub 2022 May 27.
High-throughput sequencing and functional characterization of the cancer transcriptome have uncovered cancer-specific dysregulation of RNA splicing across a variety of cancers. Alterations in the cancer genome and dysregulation of RNA splicing factors lead to missplicing, splicing alteration-dependent gene expression and, in some cases, generation of novel splicing-derived proteins. Here, we review recent advances in our understanding of aberrant splicing in cancer pathogenesis and present strategies to harness cancer-specific aberrant splicing for therapeutic intent.
高通量测序和癌症转录组的功能特征分析揭示了多种癌症中 RNA 剪接的特异性失调。癌症基因组的改变和 RNA 剪接因子的失调导致错配剪接、依赖剪接改变的基因表达，在某些情况下还会产生新的剪接衍生蛋白。在这里，我们回顾了近年来对癌症发病机制中异常剪接的理解的进展，并提出了利用癌症特异性异常剪接进行治疗的策略。
