Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
J Med Case Rep. 2022 May 28;16(1):208. doi: 10.1186/s13256-022-03423-6.
Chronic cough, with a duration of coughing of more than 8 weeks in adults, affects 5-10% of the general population. One of the most common causes of chronic cough is cough-variant asthma, which accounts for approximately one-third of cases. This phenotype of asthma is characterized by extreme sensitivity of the neuronal pathways mediating cough to environmental irritants, which results in an urge to cough. This case is an example of cough-variant asthma presenting with allergic shiners due to her severe cough.
A 38-year-old Iranian woman, who was well before the start of the coronavirus disease 2019 pandemic, presented with a nonproductive hacking cough that had begun after excessive use of antiseptic solutions. The only positive finding on physical examination was a reddish-purple rash on and around the eyelids mimicking a heliotrope rash, which had probably evolved due to the severity of the cough. The results of the pulmonary function test were within normal limits. Methacholine challenge test and chest x-ray were both normal. Chest high-resolution computed tomography revealed hyperinflation and tree-in-bud opacities. All other laboratory tests were normal. Because of the reversibility in her pulmonary function test, despite normal baseline parameters, asthma treatment was initiated, resulting in disappearance of the cough and the eye discoloration, being indicative of the correct diagnosis and proper treatment.
Patients with cough-variant asthma may often have no other classic symptoms of asthma other than cough.
成人慢性咳嗽,咳嗽持续时间超过 8 周,影响 5-10%的普通人群。慢性咳嗽最常见的原因之一是咳嗽变异性哮喘,约占病例的三分之一。这种哮喘表型的特点是介导咳嗽的神经元通路对环境刺激物极度敏感,导致咳嗽欲。本例是由于剧烈咳嗽而出现变异性哮喘的过敏性熊猫眼的病例。
一位 38 岁的伊朗妇女,在 2019 年冠状病毒病大流行之前身体状况良好,出现无痰干咳,始于过度使用消毒剂后。体格检查唯一的阳性发现是眼睑和周围出现红紫色皮疹,类似于赫洛特罗皮疹,可能由于咳嗽剧烈而出现。肺功能检查结果正常。乙酰甲胆碱激发试验和胸部 X 线均正常。胸部高分辨率计算机断层扫描显示过度充气和树芽征。所有其他实验室检查均正常。由于她的肺功能检查具有可逆性,尽管基线参数正常,但仍开始进行哮喘治疗,导致咳嗽和眼睛变色消失,这表明诊断正确,治疗得当。
咳嗽变异性哮喘患者除咳嗽外,可能常常没有其他典型的哮喘症状。