Department of Optometry, Seoul National University of Science and Technology, 232 Gongneung-ro, Nowon-gu, Seoul 01811, Korea.
Corning Technology Center Korea, Corning Precision Materials Co., Ltd., 212 Tangjeong-ro, Asan 31454, Korea.
Biosensors (Basel). 2022 Apr 22;12(5):266. doi: 10.3390/bios12050266.
Paper is a popular platform material in all areas of sensor research due to its porosity, large surface area, and biodegradability, to name but a few. Many paper-based nanocomposites have been reported in the last decade as novel substrates for surface-enhanced Raman spectroscopy (SERS). However, there are still limiting factors, like the low density of hot spots or loss of wettability. Herein, we designed a process to fabricate a silver-chitosan nanocomposite layer on paper celluloses by a layer-by-layer method and pH-triggered chitosan assembly. Under microscopic observation, the resulting material showed a nanoporous structure, and silver nanoparticles were anchored evenly over the nanocomposite layer. In SERS measurement, the detection limit of 4-aminothiophenol was 5.13 ppb. Furthermore, its mechanical property and a strategy toward further biosensing approaches were investigated.
纸因其多孔性、大表面积和生物降解性等特点，成为各个领域传感器研究中常用的平台材料。在过去的十年中，许多基于纸的纳米复合材料被报道为用于表面增强拉曼光谱（SERS）的新型基底。然而，仍然存在一些限制因素，例如热点密度低或润湿性丧失。在此，我们设计了一种通过层层法和 pH 触发壳聚糖组装在纸纤维素上制备银-壳聚糖纳米复合材料层的方法。在微观观察下，所得材料呈现纳米多孔结构，并且银纳米颗粒均匀地锚定在纳米复合材料层上。在 SERS 测量中，对 4-巯基苯胺的检测限为 5.13 ppb。此外，还研究了其机械性能和进一步生物传感方法的策略。
