Facultad de Ciencias de la Ingeniería y Tecnología, Universidad Autónoma de Baja California, Blvd. Universitario, #1000. Unidad Valle de las Palmas. Tijuana, Baja, Tijuana, CP. 21500, Baja California, México.
Facultad de Ciencias Química e Ingeniería, Universidad Autónoma de Baja California, Universidad #14418, UABC, Parque Internacional Industrial Tijuana, Tijuana, 22424, Baja California, México.
Sci Rep. 2024 Oct 24;14(1):25118. doi: 10.1038/s41598-024-75814-2.
This study investigates the fabrication and characterization of electrospun poly (ε-caprolactone)/poly (vinyl pyrrolidone) (PCL/PVP) fibers integrated with a nanocomposite of chitosan, silver nanocrystals, and graphene oxide (ChAgG), aimed at developing advanced wound dressing materials. The ChAgG nanocomposite, recognized for its antimicrobial and biocompatible properties, was incorporated into PCL/PVP fibers through electrospinning techniques. We assessed the resultant fibers' morphological, physicochemical, and mechanical properties, which exhibited significant enhancements in mechanical strength and demonstrated effective antimicrobial activity against common bacterial pathogens. The findings suggest that the PCL/PVP-ChAgG fibers maintain biocompatibility and facilitate controlled therapeutic delivery, positioning them as a promising solution for managing chronic and burn-related wounds. This study underscores the potential of these advanced materials to improve healing outcomes cost-effectively, particularly in settings plagued by high incidences of burn injuries. Further clinical investigations are recommended to explore these innovative fibers' full potential and real-world applicability.
这项研究旨在开发先进的伤口敷料材料，探讨了静电纺丝聚（ε-己内酯）/聚（聚乙烯吡咯烷酮）（PCL/PVP）纤维与壳聚糖、银纳米晶体和氧化石墨烯（ChAgG）纳米复合材料的制备和特性。ChAgG 纳米复合材料因其具有抗菌和生物相容性而被纳入 PCL/PVP 纤维中，通过静电纺丝技术实现。我们评估了所得纤维的形态、物理化学和机械性能，发现其机械强度显著提高，并对常见细菌病原体表现出有效的抗菌活性。研究结果表明，PCL/PVP-ChAgG 纤维保持生物相容性并促进了控制释放治疗，为管理慢性和烧伤相关伤口提供了一种有前途的解决方案。这项研究强调了这些先进材料具有以具有成本效益的方式改善治疗效果的潜力，特别是在烧伤发病率较高的环境中。建议进行进一步的临床研究，以探索这些创新纤维的全部潜力和实际应用。
