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场效应电容器用配体稳定的金纳米粒子修饰：建模与实验。

Field-Effect Capacitors Decorated with Ligand-Stabilized Gold Nanoparticles: Modeling and Experiments.

机构信息

MicroNanoBio, 40479 Düsseldorf, Germany.

Institute of Nano- and Biotechnologies, FH Aachen, 52428 Jülich, Germany.

出版信息

Biosensors (Basel). 2022 May 13;12(5):334. doi: 10.3390/bios12050334.

DOI:10.3390/bios12050334
PMID:35624635
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9139043/
Abstract

Nanoparticles are recognized as highly attractive tunable materials for designing field-effect biosensors with enhanced performance. In this work, we present a theoretical model for electrolyte-insulator-semiconductor capacitors (EISCAP) decorated with ligand-stabilized charged gold nanoparticles. The charged AuNPs are taken into account as additional, nanometer-sized local gates. The capacitance-voltage (-) curves and constant-capacitance (ConCap) signals of the AuNP-decorated EISCAPs have been simulated. The impact of the AuNP coverage on the shift of the - curves and the ConCap signals was also studied experimentally on Al-p-Si-SiO EISCAPs decorated with positively charged aminooctanethiol-capped AuNPs. In addition, the surface of the EISCAPs, modified with AuNPs, was characterized by scanning electron microscopy for different immobilization times of the nanoparticles.

摘要

纳米粒子被认为是极具吸引力的可调材料，可用于设计具有增强性能的场效应生物传感器。在这项工作中，我们提出了一种带有配体稳定带电金纳米粒子的电解质-绝缘体-半导体电容器 (EISCAP) 的理论模型。带电的 AuNP 被视为额外的纳米级局部门。AuNP 修饰的 EISCAP 的电容-电压 (-) 曲线和恒电容 (ConCap) 信号已被模拟。AuNP 覆盖率对 - 曲线和 ConCap 信号的偏移的影响也在带有正电荷氨辛硫醇封端的 AuNP 的 Al-p-Si-SiO EISCAP 上进行了实验研究。此外，通过扫描电子显微镜对 AuNP 修饰的 EISCAP 进行了不同的纳米粒子固定时间的表面特性进行了表征。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14de/9139043/e90534c558c3/biosensors-12-00334-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14de/9139043/b27bec08effc/biosensors-12-00334-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14de/9139043/28930363f879/biosensors-12-00334-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14de/9139043/3b194beb6f11/biosensors-12-00334-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14de/9139043/9f3c2b5355e7/biosensors-12-00334-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14de/9139043/49c64e3c6459/biosensors-12-00334-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14de/9139043/e90534c558c3/biosensors-12-00334-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14de/9139043/b27bec08effc/biosensors-12-00334-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14de/9139043/28930363f879/biosensors-12-00334-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14de/9139043/3b194beb6f11/biosensors-12-00334-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14de/9139043/9f3c2b5355e7/biosensors-12-00334-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14de/9139043/49c64e3c6459/biosensors-12-00334-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14de/9139043/e90534c558c3/biosensors-12-00334-g006.jpg

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