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通过半工业亚临界水萃取从板栗皮中提取生物活性抗氧化化合物

Bioactive Antioxidant Compounds from Chestnut Peels through Semi-Industrial Subcritical Water Extraction.

作者信息

Cravotto Christian, Grillo Giorgio, Binello Arianna, Gallina Lorenzo, Olivares-Vicente Mariló, Herranz-López María, Micol Vicente, Barrajón-Catalán Enrique, Cravotto Giancarlo

机构信息

GREEN Extraction Team, INRAE, UMR 408, Avignon University, 84000 Avignon, France.

Department of Drug Science and Technology, University of Turin, Via P. Giuria 9, 10125 Turin, Italy.

出版信息

Antioxidants (Basel). 2022 May 18;11(5):988. doi: 10.3390/antiox11050988.

DOI:10.3390/antiox11050988
PMID:35624852
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9137501/
Abstract

Chestnut peels are a poorly characterized, underexploited by-product of the agri-food industry. This raw material is rich in bioactive compounds, primarily polyphenols and tannins, that can be extracted using different green technologies. Scaling up the process for industrial production is a fundamental step for the valorization of the extract. In this study, subcritical water extraction was investigated to maximize the extraction yield and polyphenol content. Lab-scale procedures have been scaled up to the semi-industrial level as well as the downstream processes, namely, concentration and spray drying. The extract antioxidant capacity was tested using in vitro and cellular assays as well as a preliminary evaluation of its antiadipogenic activity. The temperature, extraction time, and water/solid ratio were optimized, and the extract obtained under these conditions displayed a strong antioxidant capacity both in in vitro and cellular tests. Encouraging data on the adipocyte model showed the influence of chestnut extracts on adipocyte maturation and the consequent potential antiadipogenic activity. Chestnut peel extracts characterized by strong antioxidant power and potential antiadipogenic activity were efficiently obtained by removing organic solvents. These results prompted further studies on fraction enrichment by ultra- and nanofiltration. The semi-industrial eco-friendly extraction process and downstream benefits reported here may open the door to production and commercialization.

摘要

栗皮是农业食品工业中一种特性描述不足、未得到充分利用的副产品。这种原材料富含生物活性化合物，主要是多酚和单宁，可以采用不同的绿色技术进行提取。扩大工业生产工艺规模是提取物增值的关键一步。在本研究中，对亚临界水萃取进行了研究，以最大化提取率和多酚含量。实验室规模的程序已扩大到半工业规模以及下游工艺，即浓缩和喷雾干燥。使用体外和细胞试验测试了提取物的抗氧化能力，并对其抗脂肪生成活性进行了初步评估。优化了温度、提取时间和水/固比，在这些条件下获得的提取物在体外和细胞试验中均表现出较强的抗氧化能力。在脂肪细胞模型上获得的令人鼓舞的数据显示了栗提取物对脂肪细胞成熟的影响以及随之而来的潜在抗脂肪生成活性。通过去除有机溶剂有效地获得了具有强抗氧化能力和潜在抗脂肪生成活性的栗皮提取物。这些结果促使人们进一步研究通过超滤和纳滤进行馏分富集。本文报道的半工业生态友好型提取工艺和下游优势可能为生产和商业化打开大门。

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